antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic α-helix

Lipid droplets are intracellular lipid-storage organelles that are thought to be derived from the endoplasmic reticulum (ER). Several pathogens, notably hepatitis C virus, use lipid droplets for replication. Numerous questions remain about how lipid droplets are generated and used by viruses. Here w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (48), p.20452-20457
Hauptverfasser:	Hinson, Ella R, Cresswell, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological Sciences Blotting, Western Cell Line Cell lines Cell membranes Cellular immunity Endoplasmic Reticulum - metabolism Fluorescent antibody techniques Hepacivirus Hepacivirus - metabolism Hepatocytes - metabolism Humans Infections Lipid Metabolism Lipids Macrophages - metabolism Microscopy, Fluorescence Organelles Oxidoreductases Acting on CH-CH Group Donors Point Mutation - genetics Protein Structure, Secondary Proteins Proteins - genetics Proteins - metabolism Viral Nonstructural Proteins - metabolism
Online-Zugang:	Volltext
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