Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans

Kinesin-3 motor UNC-104/KIF1A is essential for transporting synaptic precursors to synapses. Although the mechanism of cargo binding is well understood, little is known how motor activity is regulated. We mapped functional interaction domains between SYD-2 and UNC-104 by using yeast 2-hybrid and pul...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 (46), p.19605-19610
Hauptverfasser:	Wagner, Oliver I, Esposito, Alessandro, Köhler, Barbara, Chen, Chih-Wei, Shen, Che-Piao, Wu, Gong-Her, Butkevich, Eugenia, Mandalapu, Sailaja, Wenzel, Dirk, Wouters, Fred S, Klopfenstein, Dieter R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Binding sites Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell culture techniques Fluorescence Recovery After Photobleaching Fluorescence Resonance Energy Transfer Freight Gene expression regulation Imaging Microscopy Nerve Tissue Proteins - metabolism Neurons Neuroscience Phosphoproteins - genetics Phosphoproteins - metabolism Protein folding Protein Interaction Domains and Motifs Protein Interaction Mapping Proteins Synapses Synaptic Vesicles - metabolism Velocity Yeast Yeasts
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