Synergism of CAY-1 with Amphotericin B and Itraconazole

Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixe...

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Veröffentlicht in:	Chemotherapy (Basel) 2006-01, Vol.52 (6), p.285-287
Hauptverfasser:	De Lucca, A.J, Bland, J.M, Boue, S, Vigo, C.B, Cleveland, T.E, Walsh, T.J
Format:	Artikel
Sprache:	eng
Schlagworte:	amphotericin B Amphotericin B - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology antifungal properties Aspergillus Aspergillus flavus Aspergillus flavus - drug effects Aspergillus fumigatus Aspergillus fumigatus - drug effects Aspergillus niger Aspergillus niger - drug effects Biological and medical sciences Candida albicans Candida albicans - drug effects Capsicum Capsicum annuum cayenne conidia Drug Combinations Drug Resistance, Fungal - drug effects Drug Synergism Drug therapy itraconazole Itraconazole - pharmacology Medical sciences Microbial Sensitivity Tests Microbiology peppers Pesticides Pharmacology Pharmacology. Drug treatments Plant Preparations saponins Saponins - pharmacology spore germination Steroids - pharmacology synergism Time Factors
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