Intralesional Regulatory T-Cell Suppressive Function during Human Acute and Chronic Cutaneous Leishmaniasis Due to Leishmania guyanensis

The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL). We demonstrated that Treg cells preferentially accumulate in lesions from ACL patients during...

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Veröffentlicht in:	Infection and Immunity 2009-04, Vol.77 (4), p.1465-1474
Hauptverfasser:	Bourreau, E, Ronet, C, Darcissac, E, Lise, M.C, Sainte Marie, D, Clity, E, Tacchini-Cottier, F, Couppie, P, Launois, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Animals Biological and medical sciences Cellular Biology Chronic Disease Female Forkhead Transcription Factors Forkhead Transcription Factors - metabolism Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Humans Indoleamine-Pyrrole 2,3,-Dioxygenase Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Interferon-gamma Interferon-gamma - metabolism Interleukin-10 Interleukin-10 - immunology Leishmania guyanensis Leishmania guyanensis - immunology Leishmania guyanensis - pathogenicity Leishmaniasis, Cutaneous Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Life Sciences Male Microbiology Middle Aged RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Skin Skin - immunology Skin - parasitology Skin - pathology T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory - immunology Young Adult
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