Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus
Avian infectious bronchitis virus (IBV) is a major pathogen in commercial poultry flocks. We recently demonstrated that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid-binding pro...
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| Veröffentlicht in: | Avian pathology 2009-02, Vol.38 (1), p.41-45 |
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| creator | Abd El Rahman, S El-Kenawy, A.A Neumann, U Herrler, G Winter, C |
| description | Avian infectious bronchitis virus (IBV) is a major pathogen in commercial poultry flocks. We recently demonstrated that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid-binding properties. We demonstrate that sialic acid binding is important for the infection of primary chicken kidney cells and the tracheal epithelium by all four strains. There were only slight differences between the four strains, indicating the universal usage of sialic acids as receptor determinants by IBV. In addition, we analysed the primary target cells in the respiratory epithelium of the four different strains and found that all of them infected ciliated cells and goblet cells. |
| doi_str_mv | 10.1080/03079450802632049 |
| format | Article |
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We recently demonstrated that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid-binding properties. We demonstrate that sialic acid binding is important for the infection of primary chicken kidney cells and the tracheal epithelium by all four strains. There were only slight differences between the four strains, indicating the universal usage of sialic acids as receptor determinants by IBV. In addition, we analysed the primary target cells in the respiratory epithelium of the four different strains and found that all of them infected ciliated cells and goblet cells.</description><identifier>ISSN: 0307-9457</identifier><identifier>EISSN: 1465-3338</identifier><identifier>DOI: 10.1080/03079450802632049</identifier><identifier>PMID: 19156578</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject>Acids ; Animals ; Avian flu ; Avian infectious bronchitis virus ; binding capacity ; cell culture ; Cells ; Chick Embryo ; chickens ; Comparative analysis ; epithelial cells ; epithelium ; goblet cells ; in vitro studies ; infectious bronchitis ; Infectious bronchitis virus ; Infectious bronchitis virus - classification ; Infectious bronchitis virus - physiology ; kidney cells ; Kidneys ; N-Acetylneuraminic Acid - metabolism ; Ornithology ; pathogenesis ; pathogenicity ; pathotypes ; Poultry ; receptors ; Respiratory Mucosa - cytology ; Respiratory Mucosa - virology ; sialic acids ; strain differences ; strains ; tissue tropism ; trachea (vertebrates) ; Trachea - cytology ; Tropism - physiology</subject><ispartof>Avian pathology, 2009-02, Vol.38 (1), p.41-45</ispartof><rights>Copyright Houghton Trust Ltd 2009</rights><rights>Copyright Taylor & Francis Ltd. Feb 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-73e3e1413d2298e29a100cc43a2aa2ee2c4c6aca19922feb5cca97ae3f65e3f3</citedby><cites>FETCH-LOGICAL-c591t-73e3e1413d2298e29a100cc43a2aa2ee2c4c6aca19922feb5cca97ae3f65e3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19156578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abd El Rahman, S</creatorcontrib><creatorcontrib>El-Kenawy, A.A</creatorcontrib><creatorcontrib>Neumann, U</creatorcontrib><creatorcontrib>Herrler, G</creatorcontrib><creatorcontrib>Winter, C</creatorcontrib><title>Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus</title><title>Avian pathology</title><addtitle>Avian Pathol</addtitle><description>Avian infectious bronchitis virus (IBV) is a major pathogen in commercial poultry flocks. We recently demonstrated that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid-binding properties. We demonstrate that sialic acid binding is important for the infection of primary chicken kidney cells and the tracheal epithelium by all four strains. There were only slight differences between the four strains, indicating the universal usage of sialic acids as receptor determinants by IBV. In addition, we analysed the primary target cells in the respiratory epithelium of the four different strains and found that all of them infected ciliated cells and goblet cells.</description><subject>Acids</subject><subject>Animals</subject><subject>Avian flu</subject><subject>Avian infectious bronchitis virus</subject><subject>binding capacity</subject><subject>cell culture</subject><subject>Cells</subject><subject>Chick Embryo</subject><subject>chickens</subject><subject>Comparative analysis</subject><subject>epithelial cells</subject><subject>epithelium</subject><subject>goblet cells</subject><subject>in vitro studies</subject><subject>infectious bronchitis</subject><subject>Infectious bronchitis virus</subject><subject>Infectious bronchitis virus - classification</subject><subject>Infectious bronchitis virus - physiology</subject><subject>kidney cells</subject><subject>Kidneys</subject><subject>N-Acetylneuraminic Acid - metabolism</subject><subject>Ornithology</subject><subject>pathogenesis</subject><subject>pathogenicity</subject><subject>pathotypes</subject><subject>Poultry</subject><subject>receptors</subject><subject>Respiratory Mucosa - cytology</subject><subject>Respiratory Mucosa - virology</subject><subject>sialic acids</subject><subject>strain differences</subject><subject>strains</subject><subject>tissue tropism</subject><subject>trachea (vertebrates)</subject><subject>Trachea - cytology</subject><subject>Tropism - physiology</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEokPhAdiAxYJdwJc4F4kNGlFAqsSCso7OOHZ7qiQOtjOQF-I5e2YyEhKV6MbX7_99fP4seyn4O8Fr_p4rXjWFpqUsleRF8yjbiKLUuVKqfpxtDvc5AdVZ9izGW855qbV8mp2JRuhSV_Um-7P1wwQBEu4tgxH6JWJk3rF0Y1lE6NEwMNixHY4djte0IRTTQnB3hFLwE8aBOR-O-2DjhGTow8LshHTU4zwcLJ2fA-vQORvsmFhMAXA8PgZ7hJHh6Cy5-zmyXfCjucFEtewxzPF59sRBH-2L03yeXV18utp-yS-_ff66_XiZG92IlFfKKisKoTopm9rKBgTnxhQKJIC0VprClGBANI2Uzu60MdBUYJUrNQ3qPHu72k7B_5xtTO2A0di-h9FSWW1Z1kppzh8EKYxKClEQ-OYf8Ja6QH1eGcWFaggSK2SCjzFY104BBwhLK3h7SLq9lzRpXp2M591gu7-KU7QEVCtAbfVhgF8-9F2bYOl9cAFGg_G-bZt-J1J-eFCp_lfZ61XuwLdwHYj-8V3SR7koeSF1re4AzUPV-w</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Abd El Rahman, S</creator><creator>El-Kenawy, A.A</creator><creator>Neumann, U</creator><creator>Herrler, G</creator><creator>Winter, C</creator><general>Taylor & Francis Group</general><general>Taylor & Francis Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus</title><author>Abd El Rahman, S ; El-Kenawy, A.A ; Neumann, U ; Herrler, G ; Winter, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-73e3e1413d2298e29a100cc43a2aa2ee2c4c6aca19922feb5cca97ae3f65e3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Avian flu</topic><topic>Avian infectious bronchitis virus</topic><topic>binding capacity</topic><topic>cell culture</topic><topic>Cells</topic><topic>Chick Embryo</topic><topic>chickens</topic><topic>Comparative analysis</topic><topic>epithelial cells</topic><topic>epithelium</topic><topic>goblet cells</topic><topic>in vitro studies</topic><topic>infectious bronchitis</topic><topic>Infectious bronchitis virus</topic><topic>Infectious bronchitis virus - classification</topic><topic>Infectious bronchitis virus - physiology</topic><topic>kidney cells</topic><topic>Kidneys</topic><topic>N-Acetylneuraminic Acid - metabolism</topic><topic>Ornithology</topic><topic>pathogenesis</topic><topic>pathogenicity</topic><topic>pathotypes</topic><topic>Poultry</topic><topic>receptors</topic><topic>Respiratory Mucosa - cytology</topic><topic>Respiratory Mucosa - virology</topic><topic>sialic acids</topic><topic>strain differences</topic><topic>strains</topic><topic>tissue tropism</topic><topic>trachea (vertebrates)</topic><topic>Trachea - cytology</topic><topic>Tropism - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abd El Rahman, S</creatorcontrib><creatorcontrib>El-Kenawy, A.A</creatorcontrib><creatorcontrib>Neumann, U</creatorcontrib><creatorcontrib>Herrler, G</creatorcontrib><creatorcontrib>Winter, C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Avian pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abd El Rahman, S</au><au>El-Kenawy, A.A</au><au>Neumann, U</au><au>Herrler, G</au><au>Winter, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>38</volume><issue>1</issue><spage>41</spage><epage>45</epage><pages>41-45</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>Avian infectious bronchitis virus (IBV) is a major pathogen in commercial poultry flocks. We recently demonstrated that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid-binding properties. We demonstrate that sialic acid binding is important for the infection of primary chicken kidney cells and the tracheal epithelium by all four strains. There were only slight differences between the four strains, indicating the universal usage of sialic acids as receptor determinants by IBV. In addition, we analysed the primary target cells in the respiratory epithelium of the four different strains and found that all of them infected ciliated cells and goblet cells.</abstract><cop>England</cop><pub>Taylor & Francis Group</pub><pmid>19156578</pmid><doi>10.1080/03079450802632049</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Animals Avian flu Avian infectious bronchitis virus binding capacity cell culture Cells Chick Embryo chickens Comparative analysis epithelial cells epithelium goblet cells in vitro studies infectious bronchitis Infectious bronchitis virus Infectious bronchitis virus - classification Infectious bronchitis virus - physiology kidney cells Kidneys N-Acetylneuraminic Acid - metabolism Ornithology pathogenesis pathogenicity pathotypes Poultry receptors Respiratory Mucosa - cytology Respiratory Mucosa - virology sialic acids strain differences strains tissue tropism trachea (vertebrates) Trachea - cytology Tropism - physiology |
| title | Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus |
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