Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice

Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining calcium homeostasis. The osteoclast creates an enclosed space, a lacuna, between their ruffled border membrane and the mineralized bone. They extrude H⁺ and Cl⁻ into these lacun...

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