Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serineí 65 Phosphorylation

The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser⁶⁵ of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser⁶⁵ with...

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Veröffentlicht in:	The Journal of biological chemistry 2009-01, Vol.284 (2), p.759-765
Hauptverfasser:	Guo, Shuangli, Burnette, Ryan, Zhao, Li, Vanderford, Nathan L, Poitout, Vincent, Hagman, Derek K, Henderson, Eva, Özcan, Sabire, Wadzinski, Brian E, Stein, Roland
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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