SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent transcriptional repression. We generated a knockin mutation in the receptor interaction domain (RID) of S...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (50), p.20021-20026
Hauptverfasser:	Nofsinger, Russell R, Li, Pingping, Hong, Suk-Hyun, Jonker, Johan W, Barish, Grant D, Ying, Hao, Cheng, Sheue-yann, LeBlanc, Mathias, Xu, Wei, Pei, Liming, Kang, Yeon-Joo, Nelson, Michael, Downes, Michael, Yu, Ruth T, Olefsky, Jerrold M, Lee, Chih-Hao, Evans, Ronald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipogenesis - genetics Animals Biological Sciences Cell lines Chromatin Immunoprecipitation Co repressor proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Gene Expression Regulation Gene Knock-In Techniques Genes Genes, Lethal Genetic mutation Glucose Glucose - metabolism Homeostasis - genetics Hormones Insulin Ligands Lipogenesis Metabolism Mice Mice, Mutant Strains Mutation Nuclear Receptor Co-Repressor 2 PPAR gamma - metabolism Protein Structure, Tertiary Repression Repressor Proteins - genetics Repressor Proteins - metabolism Rodents Thyroid Hormone Receptors alpha - genetics Thyroid Hormone Receptors beta - genetics Thyroid Hormones - metabolism
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