Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis

SigH is a key regulator of an extensive transcriptional network that responds to oxidative, nitrosative, and heat stresses in Mycobacterium tuberculosis, and this sigma factor is required for virulence in animal models of infection. SigH is negatively regulated by RshA, its cognate anti-sigma factor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (35), p.13105-13110
Hauptverfasser:	Park, Sang Tae, Kang, Choong-Min, Husson, Robert N
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - metabolism Biological Sciences Cells Disulfides - metabolism Gels Gene expression Gene expression regulation Intracellular Signaling Peptides and Proteins - metabolism Kinases Molecules Mycobacterium tuberculosis Mycobacterium tuberculosis - cytology Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Oxidative stress Phosphatases Phosphoric Monoester Hydrolases - pharmacology Phosphorylation Phosphorylation - drug effects Protein Binding - drug effects Protein-Serine-Threonine Kinases - metabolism Proteins Regulon Regulon - genetics Sigma Factor - metabolism Signal transduction Stress response Transcriptional regulatory elements Tuberculosis
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