Long-range cis preferences in DNA homology search over the length of a Drosophila chromosome
P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent wh...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1994, Vol.263 (5153), p.1623-1625 |
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| container_issue | 5153 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Engels, W.R Preston, C.R Johnson-Schlitz, D.M |
| description | P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA. |
| format | Article |
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Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. 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Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.</description><subject>DNA</subject><subject>Drosophila melanogaster</subject><subject>X chromosome</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFi8sKwjAQRYMoWB_f4PxAYdr4aJfiAxfiRt0JJZRpUokZyYjg39uFe1eXwzm3p5IMy0Va5qj7KkHUy7TA1WKoRiJ3xM6VOlG3IwebRhMsQd0KPCM1FCnUJNAG2J7W4PjBnu0HhEysHfCbIrwcgadgXx03YGAbWfjpWm-gdrF7CD9oogaN8ULT347VbL-7bA5pY7gyNrZSXc85ZhqzeVHqQuv_xRcUfz8G</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Engels, W.R</creator><creator>Preston, C.R</creator><creator>Johnson-Schlitz, D.M</creator><scope>FBQ</scope></search><sort><creationdate>1994</creationdate><title>Long-range cis preferences in DNA homology search over the length of a Drosophila chromosome</title><author>Engels, W.R ; Preston, C.R ; Johnson-Schlitz, D.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-fao_agris_US2013014893833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>DNA</topic><topic>Drosophila melanogaster</topic><topic>X chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engels, W.R</creatorcontrib><creatorcontrib>Preston, C.R</creatorcontrib><creatorcontrib>Johnson-Schlitz, D.M</creatorcontrib><collection>AGRIS</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engels, W.R</au><au>Preston, C.R</au><au>Johnson-Schlitz, D.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-range cis preferences in DNA homology search over the length of a Drosophila chromosome</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>1994</date><risdate>1994</risdate><volume>263</volume><issue>5153</issue><spage>1623</spage><epage>1625</epage><pages>1623-1625</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.</abstract></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1994, Vol.263 (5153), p.1623-1625 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_fao_agris_US201301489383 |
| source | Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | DNA Drosophila melanogaster X chromosome |
| title | Long-range cis preferences in DNA homology search over the length of a Drosophila chromosome |
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