Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of α7 nicotinic receptor in oral keratinocytes

The use of tobacco products is associated with an increased incidence of periodontal disease, poor response to periodontal therapy, and a high risk for developing head and neck cancer. Nicotine and tobacco-derived nitrosamines have been shown to exhibit their pathobiologic effects due in part to act...

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Veröffentlicht in:	The FASEB journal 2006-10, Vol.20 (12), p.2093-2101
Hauptverfasser:	Arredondo, Juan, Chernyavsky, Alexander I, Jolkovsky, David L, Pinkerton, Kent E, Grando, Sergei A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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