Probiotics Reduce Enterohemorrhagic Escherichia coli O157:H7- and Enteropathogenic E. coli O127:H6-Induced Changes in Polarized T84 Epithelial Cell Monolayers by Reducing Bacterial Adhesion and Cytoskeletal Rearrangements

The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance....

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Veröffentlicht in:	Infection and Immunity 2005-08, Vol.73 (8), p.5183-5188
Hauptverfasser:	Sherman, Philip M, Johnson-Henry, Kathene C, Yeung, Helen P, Ngo, Peter S. C, Goulet, Jacques, Tompkins, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - metabolism Bacterial Adhesion - physiology Bacteriology Biological and medical sciences Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Cytoskeleton - metabolism Epithelial Cells - metabolism Epithelial Cells - microbiology Escherichia coli Infections - metabolism Escherichia coli Infections - therapy Escherichia coli O157 - metabolism Fundamental and applied biological sciences. Psychology Humans Lactobacillus acidophilus - metabolism Microbiology Miscellaneous Probiotics - metabolism
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Zusammenfassung:	The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance. These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.8.5183-5188.2005