Antimalarial ethnobotany: in vitro antiplasmodial activity of seven plants identified in the Nigerian middle belt
Abstract Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were...
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| Veröffentlicht in: | Pharmaceutical biology 2005-01, Vol.42 (8), p.588-591 |
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| creator | Ajaiyeoba, E Ashidi, J Abiodun, O Okpako, L Ogbole, O Akinboye, D Falade, C Bolaji, O Gbotosho, G Falade, M |
| description | Abstract
Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro. antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum. K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in µg ml. Of the seven plants screened, Erythrina senegalensis. DC (Leguminosae), Pericopsis elata. Harms (Papilionaceae), and Bridelia micrantha. Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 µg ml, respectively. Nauclea latifolia. SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 µg ml. |
| doi_str_mv | 10.1080/13880200490902455 |
| format | Article |
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Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro. antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum. K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in µg ml. Of the seven plants screened, Erythrina senegalensis. DC (Leguminosae), Pericopsis elata. Harms (Papilionaceae), and Bridelia micrantha. Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 µg ml, respectively. Nauclea latifolia. SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 µg ml.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880200490902455</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Antiplasmodial activity ; Biological and medical sciences ; Bridelia micrantha ; Erythrina senegalensis ; ethnobotany ; Fabaceae ; General pharmacology ; Medical sciences ; Middle Belt ; Nigeria ; Papilionaceae ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytomedicine ; Plasmodium falciparum ; Rubiaceae</subject><ispartof>Pharmaceutical biology, 2005-01, Vol.42 (8), p.588-591</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-f60abef32e5a70d2a10b3b4e3a46e36f1dd723a20316ac5914641748571e340d3</citedby><cites>FETCH-LOGICAL-c478t-f60abef32e5a70d2a10b3b4e3a46e36f1dd723a20316ac5914641748571e340d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13880200490902455$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13880200490902455$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,59656,60445,61230,61411</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16564803$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajaiyeoba, E</creatorcontrib><creatorcontrib>Ashidi, J</creatorcontrib><creatorcontrib>Abiodun, O</creatorcontrib><creatorcontrib>Okpako, L</creatorcontrib><creatorcontrib>Ogbole, O</creatorcontrib><creatorcontrib>Akinboye, D</creatorcontrib><creatorcontrib>Falade, C</creatorcontrib><creatorcontrib>Bolaji, O</creatorcontrib><creatorcontrib>Gbotosho, G</creatorcontrib><creatorcontrib>Falade, M</creatorcontrib><title>Antimalarial ethnobotany: in vitro antiplasmodial activity of seven plants identified in the Nigerian middle belt</title><title>Pharmaceutical biology</title><description>Abstract
Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro. antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum. K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in µg ml. Of the seven plants screened, Erythrina senegalensis. DC (Leguminosae), Pericopsis elata. Harms (Papilionaceae), and Bridelia micrantha. Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 µg ml, respectively. Nauclea latifolia. SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 µg ml.</description><subject>Antiplasmodial activity</subject><subject>Biological and medical sciences</subject><subject>Bridelia micrantha</subject><subject>Erythrina senegalensis</subject><subject>ethnobotany</subject><subject>Fabaceae</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Middle Belt</subject><subject>Nigeria</subject><subject>Papilionaceae</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytomedicine</subject><subject>Plasmodium falciparum</subject><subject>Rubiaceae</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kE9v1DAQxSMEEqXwATjhC9wC49hOssClqvhTqSoH6NmaxOOuK8fe2t5W--3r1RYhVKknW3q_92bmNc1bDh85jPCJi3GEDkCuYAWdVOpZc8QHKVvFef-8_qveVmD1snmV8zUAKCHUUXNzEopb0GNy6BmVdYhTLBh2n5kL7NaVFBlWZOMxL9HsIZyLq8KORcsy3VJgVQwlM2eoktaR2XvLmtiFu6IaHNjijPHEJvLldfPCos_05uE9bi6_f_tz-rM9__Xj7PTkvJ3lMJbW9oATWdGRwgFMhxwmMUkSKHsSveXGDJ3ADgTvcVYrLntZDx7VwElIMOK4-XDI3aR4s6Vc9OLyTL7uSnGbNR9GMXairyA_gHOKOSeyepNqJWmnOeh9ufpRudXz_iEc84zeJgyzy_-MverlCKJyXw-cCzamBe9i8kYX3PmY_prEU2O-_GdfE_qynjGRvo7bFGp_Ty757uC2GDVepTrr8ncHXACvmBqluAfhK6jo</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Ajaiyeoba, E</creator><creator>Ashidi, J</creator><creator>Abiodun, O</creator><creator>Okpako, L</creator><creator>Ogbole, O</creator><creator>Akinboye, D</creator><creator>Falade, C</creator><creator>Bolaji, O</creator><creator>Gbotosho, G</creator><creator>Falade, M</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>20050101</creationdate><title>Antimalarial ethnobotany: in vitro antiplasmodial activity of seven plants identified in the Nigerian middle belt</title><author>Ajaiyeoba, E ; Ashidi, J ; Abiodun, O ; Okpako, L ; Ogbole, O ; Akinboye, D ; Falade, C ; Bolaji, O ; Gbotosho, G ; Falade, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-f60abef32e5a70d2a10b3b4e3a46e36f1dd723a20316ac5914641748571e340d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antiplasmodial activity</topic><topic>Biological and medical sciences</topic><topic>Bridelia micrantha</topic><topic>Erythrina senegalensis</topic><topic>ethnobotany</topic><topic>Fabaceae</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Middle Belt</topic><topic>Nigeria</topic><topic>Papilionaceae</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytomedicine</topic><topic>Plasmodium falciparum</topic><topic>Rubiaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajaiyeoba, E</creatorcontrib><creatorcontrib>Ashidi, J</creatorcontrib><creatorcontrib>Abiodun, O</creatorcontrib><creatorcontrib>Okpako, L</creatorcontrib><creatorcontrib>Ogbole, O</creatorcontrib><creatorcontrib>Akinboye, D</creatorcontrib><creatorcontrib>Falade, C</creatorcontrib><creatorcontrib>Bolaji, O</creatorcontrib><creatorcontrib>Gbotosho, G</creatorcontrib><creatorcontrib>Falade, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajaiyeoba, E</au><au>Ashidi, J</au><au>Abiodun, O</au><au>Okpako, L</au><au>Ogbole, O</au><au>Akinboye, D</au><au>Falade, C</au><au>Bolaji, O</au><au>Gbotosho, G</au><au>Falade, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimalarial ethnobotany: in vitro antiplasmodial activity of seven plants identified in the Nigerian middle belt</atitle><jtitle>Pharmaceutical biology</jtitle><date>2005-01-01</date><risdate>2005</risdate><volume>42</volume><issue>8</issue><spage>588</spage><epage>591</epage><pages>588-591</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Abstract
Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro. antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum. K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC50) in µg ml. Of the seven plants screened, Erythrina senegalensis. DC (Leguminosae), Pericopsis elata. Harms (Papilionaceae), and Bridelia micrantha. Benth (Fabaceae) had IC50 values of 99.7, 124.8, and 158.7 µg ml, respectively. Nauclea latifolia. SM (Rubiaceae) extract exhibited the least activity in the assay with an IC50 value of 478.9 µg ml.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><doi>10.1080/13880200490902455</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis:Master (3349 titles); Alma/SFX Local Collection |
| subjects | Antiplasmodial activity Biological and medical sciences Bridelia micrantha Erythrina senegalensis ethnobotany Fabaceae General pharmacology Medical sciences Middle Belt Nigeria Papilionaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytomedicine Plasmodium falciparum Rubiaceae |
| title | Antimalarial ethnobotany: in vitro antiplasmodial activity of seven plants identified in the Nigerian middle belt |
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