Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment

Uncertainties have existed regarding the systematic induction and management of drug-induced diabetes mellitus (DM). Issues have included the optimal route of administration of the drug, methods of reducing drug toxicosis and mortality, how to induce type-1 versus type-2 DM, and how to manage labile...

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Veröffentlicht in:	Comparative medicine 2004-06, Vol.54 (3), p.252-257
Hauptverfasser:	Federiuk, I.F, Casey, H.M, Quinn, M.J, Wood, M.D, Ward, W.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan - administration & dosage animal disease models Animals Blood Glucose - analysis Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Disease Models, Animal Insulin - therapeutic use insulin-dependent diabetes mellitus intraperitoneal injection intravenous injection laboratory animals Rats
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