Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2
Immunosuppression resulting from infectious bursal disease virus (IBDV) infection has critical health and welfare implications for birds, yet it is incompletely understood and largely overlooked as a measure of vaccine efficacy. The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 p...
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| Veröffentlicht in: | Avian pathology 2003-12, Vol.32 (6), p.597-604 |
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| creator | Butter, C Sturman, T.D.M Baaten, B.J.G Davison, T.F |
| description | Immunosuppression resulting from infectious bursal disease virus (IBDV) infection has critical health and welfare implications for birds, yet it is incompletely understood and largely overlooked as a measure of vaccine efficacy. The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. These results indicate that measurement of immunosuppression could be a useful strategy for assessing the efficacy of vaccines to protect against the consequences of IBDV infection. |
| doi_str_mv | 10.1080/03079450310001610686 |
| format | Article |
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The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. 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The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. These results indicate that measurement of immunosuppression could be a useful strategy for assessing the efficacy of vaccines to protect against the consequences of IBDV infection.</description><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - blood</subject><subject>antibody formation</subject><subject>Bacterial Vaccines</subject><subject>Birnaviridae Infections - immunology</subject><subject>Birnaviridae Infections - prevention & control</subject><subject>Birnaviridae Infections - veterinary</subject><subject>chickens</subject><subject>Chickens - immunology</subject><subject>Drug therapy</subject><subject>Fowlpox - immunology</subject><subject>Fowlpox - prevention & control</subject><subject>Fowlpox virus</subject><subject>Fowlpox virus - immunology</subject><subject>Fowlpoxvirus</subject><subject>Immunization</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunoglobulin M - blood</subject><subject>Immunology</subject><subject>immunosuppression (physiological)</subject><subject>Infectious bursal disease virus</subject><subject>Infectious bursal disease virus - immunology</subject><subject>Infectious diseases</subject><subject>Poultry Diseases - immunology</subject><subject>Poultry Diseases - prevention & control</subject><subject>Poultry Diseases - virology</subject><subject>Random Allocation</subject><subject>recombinant vaccines</subject><subject>Salmonella enteritidis - immunology</subject><subject>Salmonella Infections, Animal - prevention & control</subject><subject>Specific Pathogen-Free Organisms</subject><subject>vaccine development</subject><subject>Vaccines, Synthetic</subject><subject>Viral Structural Proteins - immunology</subject><subject>Viral Vaccines</subject><subject>Wildfowl</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYso7rj6DUSDD6IP1Zt_TeqL6PpvYcEF3X0NaZquWdqkJq2z45fwK5uZDgiyME8hh9853HtPUTzG8AqDhNdAQdSMA8UAgCsMlazuFCvMKl5SSuXdYrVFysyIo-JBSteZqzgn94ujDIkKMKyKP-cxTNZMLnjUxTAg57vdd06omWPSPWpdsjpZ9MvFLL44ff_h8mXpfDsb2yI3DLMPaR7HaFPapjSbRXS_9S517aYfSKMurPsx3KBoTRga57WfkAl-0s47f4W2qeXlOXlY3Ot0n-yj_XtcXHz6-P3kS3n29fPpybuz0nAqp5LLpiItIxjLfARNtdSi0ZYbYFoSYDVpdyLUtOkYFY1kkhMuGsKkaQ2hx8XzJXeM4eds06QGl4zte-1t3l0JzATJRzoIYgkE15Rn8Nl_4HWYo89LqDyQwAIqnCG2QCaGlKLt1BjdoONGYVDbWtVttWbbk3323Ay2_Wfa95iBNwuQ6wtx0OsQ-1ZNetOH2EXtjUu3JqvpZsrmtwfN9MB8T5eETgelr2I2XHwjgCnkAmoJgv4FIgvNmw</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Butter, C</creator><creator>Sturman, T.D.M</creator><creator>Baaten, B.J.G</creator><creator>Davison, T.F</creator><general>Taylor &Francis</general><general>Taylor & Francis Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2</title><author>Butter, C ; Sturman, T.D.M ; Baaten, B.J.G ; Davison, T.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-58b62d42118794a3a8a7bae5c04a820492da3a8a093bf437b8485257b248cdc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibodies, Viral - blood</topic><topic>antibody formation</topic><topic>Bacterial Vaccines</topic><topic>Birnaviridae Infections - immunology</topic><topic>Birnaviridae Infections - prevention & control</topic><topic>Birnaviridae Infections - veterinary</topic><topic>chickens</topic><topic>Chickens - immunology</topic><topic>Drug therapy</topic><topic>Fowlpox - immunology</topic><topic>Fowlpox - prevention & control</topic><topic>Fowlpox virus</topic><topic>Fowlpox virus - immunology</topic><topic>Fowlpoxvirus</topic><topic>Immunization</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunoglobulin M - blood</topic><topic>Immunology</topic><topic>immunosuppression (physiological)</topic><topic>Infectious bursal disease virus</topic><topic>Infectious bursal disease virus - immunology</topic><topic>Infectious diseases</topic><topic>Poultry Diseases - immunology</topic><topic>Poultry Diseases - prevention & control</topic><topic>Poultry Diseases - virology</topic><topic>Random Allocation</topic><topic>recombinant vaccines</topic><topic>Salmonella enteritidis - immunology</topic><topic>Salmonella Infections, Animal - prevention & control</topic><topic>Specific Pathogen-Free Organisms</topic><topic>vaccine development</topic><topic>Vaccines, Synthetic</topic><topic>Viral Structural Proteins - immunology</topic><topic>Viral Vaccines</topic><topic>Wildfowl</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butter, C</creatorcontrib><creatorcontrib>Sturman, T.D.M</creatorcontrib><creatorcontrib>Baaten, B.J.G</creatorcontrib><creatorcontrib>Davison, T.F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Avian pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butter, C</au><au>Sturman, T.D.M</au><au>Baaten, B.J.G</au><au>Davison, T.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>32</volume><issue>6</issue><spage>597</spage><epage>604</epage><pages>597-604</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>Immunosuppression resulting from infectious bursal disease virus (IBDV) infection has critical health and welfare implications for birds, yet it is incompletely understood and largely overlooked as a measure of vaccine efficacy. The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. These results indicate that measurement of immunosuppression could be a useful strategy for assessing the efficacy of vaccines to protect against the consequences of IBDV infection.</abstract><cop>England</cop><pub>Taylor &Francis</pub><pmid>14676010</pmid><doi>10.1080/03079450310001610686</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Avian pathology, 2003-12, Vol.32 (6), p.597-604 |
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| language | eng |
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| source | MEDLINE; IngentaConnect Open Access; EZB Electronic Journals Library |
| subjects | Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood antibody formation Bacterial Vaccines Birnaviridae Infections - immunology Birnaviridae Infections - prevention & control Birnaviridae Infections - veterinary chickens Chickens - immunology Drug therapy Fowlpox - immunology Fowlpox - prevention & control Fowlpox virus Fowlpox virus - immunology Fowlpoxvirus Immunization Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunology immunosuppression (physiological) Infectious bursal disease virus Infectious bursal disease virus - immunology Infectious diseases Poultry Diseases - immunology Poultry Diseases - prevention & control Poultry Diseases - virology Random Allocation recombinant vaccines Salmonella enteritidis - immunology Salmonella Infections, Animal - prevention & control Specific Pathogen-Free Organisms vaccine development Vaccines, Synthetic Viral Structural Proteins - immunology Viral Vaccines Wildfowl |
| title | Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2 |
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