Genetic dissection of the biosynthetic route to gentamicin A₂ by heterologous expression of its minimal gene set

Since the first use of streptomycin as an effective antibiotic drug in the treatment of tuberculosis, aminoglycoside antibiotics have been widely used against a variety of bacterial infections for over six decades. However, the pathways for aminoglycoside biosynthesis still remain unclear, mainly be...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-06, Vol.105 (24), p.8399-8404
Hauptverfasser:	Park, Je Won, Hong, Jay Sung Joong, Parajuli, Niranjan, Jung, Won Seok, Park, Sung Ryeol, Lim, Si-Kyu, Sohng, Jae Kyung, Yoon, Yeo Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Aminoglycosides - biosynthesis Aminoglycosides - genetics Antibiotics Base Sequence Biochemical pathways Biological Sciences Biosynthesis Chromatography, High Pressure Liquid Dehydrogenases Disaccharides - biosynthesis Disaccharides - genetics Drug Resistance, Bacterial - genetics Enzymes Gene Expression Genes, Bacterial Gentamicins - biosynthesis Gentamicins - isolation & purification Hexosamines - biosynthesis Hexosamines - genetics Micromonospora Micromonospora - genetics Molecular Sequence Data Multigene Family N-Acylsphingosine Galactosyltransferase - genetics N-Acylsphingosine Galactosyltransferase - metabolism Plasmids Spectrometry, Mass, Electrospray Ionization Streptomyces Streptomyces - enzymology Streptomyces - genetics
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