Counting membrane-embedded KCNE β-subunits in functioning K⁺ channel complexes

Ion channels are multisubunit proteins responsible for the generation and propagation of action potentials in nerve, skeletal muscle, and heart as well as maintaining salt and water homeostasis in epithelium. The subunit composition and stoichiometry of these membrane protein complexes underlies the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-02, Vol.105 (5), p.1478-1482
Hauptverfasser:	Morin, Trevor J, Kobertz, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Membrane - chemistry Cell Membrane - drug effects Cell Membrane - metabolism Charybdotoxin - analogs & derivatives Charybdotoxin - chemical synthesis Charybdotoxin - chemistry Charybdotoxin - pharmacology Disulfides - chemical synthesis Disulfides - chemistry Disulfides - pharmacology Electric potential Humans Ion channels KCNQ1 Potassium Channel - analysis KCNQ1 Potassium Channel - antagonists & inhibitors KCNQ1 Potassium Channel - metabolism Kinetics Messenger RNA Oocytes Oocytes - metabolism Physical Sciences Potassium Channels, Voltage-Gated - analysis Potassium Channels, Voltage-Gated - antagonists & inhibitors Potassium Channels, Voltage-Gated - metabolism Protein Subunits - analysis Protein Subunits - antagonists & inhibitors Protein Subunits - metabolism Reagents Research design Stoichiometry Thiols Toxins Xenopus
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