Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype

Dactylaplasia, characterized by missing central digital rays, is an inherited mouse limb malformation that depends on two genetic loci. The first locus, Dac, is an insertional mutation around the dactylin gene that is inherited as a semidominant trait. The second locus is an unlinked modifier, mdac/...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (48), p.19034-19039
Hauptverfasser:	Kano, Hiroki, Kurahashi, Hiroki, Toda, Tatsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Biological Sciences Chromatin Chromosome Mapping Chromosomes DNA Methylation Embryos Epigenesis, Genetic - genetics Extremities - embryology F-Box Proteins - genetics Fibroblast Growth Factor 8 - genetics Gene expression Gene Expression Regulation - genetics Gene loci Genes Genetic loci Genomes Genomics Genotype & phenotype Histones Histones - metabolism Limb Deformities, Congenital - embryology Limb Deformities, Congenital - genetics Methylation Mice Mice, Inbred C57BL Mice, Mutant Strains Molecular Sequence Data Mutagenesis, Insertional Phenotype Phenotypes Polymerase chain reaction Protein Processing, Post-Translational Regulatory Sequences, Nucleic Acid Retroelements - genetics Retrotransposons Rodents Terminal Repeat Sequences - genetics
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