Study of two devices used to maintain normothermia in rats and mice during general anesthesia
Rodents are very susceptible to hypothermia during anesthetic events because of their high body surface-to-mass ratio. This study examined the effectiveness of 2 heating devices, a heatpad and a circulating hot-water blanket, during 60 min of isoflurane general anesthesia in rats and mice (n = 6 per...
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| Veröffentlicht in: | Journal of the American Association for Laboratory Animal Science 2007-09, Vol.46 (5), p.37-41 |
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| description | Rodents are very susceptible to hypothermia during anesthetic events because of their high body surface-to-mass ratio. This study examined the effectiveness of 2 heating devices, a heatpad and a circulating hot-water blanket, during 60 min of isoflurane general anesthesia in rats and
mice (n = 6 per treatment). In addition, 1 control group of animals for each species was anesthetized with no heat source (n = 6). Both devices carried minimal risk of causing thermal burns or hyperthermia. Rats on the circulating water blanket showed a slight decrease (0.11 ± 0.19
°C) from the initial (time 0) body temperature (mean ± standard error), whereas the heatpad was associated with a significant increase (0.96 ± 0.10 °C). Mice on the circulating water blanket showed a significant decrease (0.46 ± 0.05 °C) in body temperature.
The trend in mice on the heatpad was similar to that in rats, with a significant increase (0.94 ± 0.13 °C) from the body temperature at time 0. Although statistically significant, these deviations from baseline body temperature were not considered physiologically relevant. In comparison,
body temperatures decreased significantly in rats and mice (4.42 ± 0.60 and 9.90 ± 0.35 °C, respectively) with no heat source. Both heating devices were safe and effective, but the low cost, ease of maintenance, and portability of the heatpad may make it a more desirable
choice in some facilities. |
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mice (n = 6 per treatment). In addition, 1 control group of animals for each species was anesthetized with no heat source (n = 6). Both devices carried minimal risk of causing thermal burns or hyperthermia. Rats on the circulating water blanket showed a slight decrease (0.11 ± 0.19
°C) from the initial (time 0) body temperature (mean ± standard error), whereas the heatpad was associated with a significant increase (0.96 ± 0.10 °C). Mice on the circulating water blanket showed a significant decrease (0.46 ± 0.05 °C) in body temperature.
The trend in mice on the heatpad was similar to that in rats, with a significant increase (0.94 ± 0.13 °C) from the body temperature at time 0. Although statistically significant, these deviations from baseline body temperature were not considered physiologically relevant. In comparison,
body temperatures decreased significantly in rats and mice (4.42 ± 0.60 and 9.90 ± 0.35 °C, respectively) with no heat source. Both heating devices were safe and effective, but the low cost, ease of maintenance, and portability of the heatpad may make it a more desirable
choice in some facilities.</description><identifier>ISSN: 1559-6109</identifier><identifier>EISSN: 2769-6677</identifier><identifier>PMID: 17877326</identifier><language>eng</language><publisher>United States: American Association for Laboratory Animal Science</publisher><subject>anesthesia ; Anesthesia, General - adverse effects ; Animals ; body temperature changes ; Body Temperature Regulation ; Equipment Design ; equipment performance ; Female ; general anesthetics ; Heating - instrumentation ; heating systems ; heatpad ; hot-water blanket ; hypothermia ; Hypothermia - etiology ; Hypothermia - prevention & control ; Intraoperative Care ; isoflurane ; Laboratory Animal Science - instrumentation ; Laboratory Animal Science - methods ; Male ; Mice ; Mice, Inbred Strains ; Rats ; Rats, Sprague-Dawley ; veterinary equipment</subject><ispartof>Journal of the American Association for Laboratory Animal Science, 2007-09, Vol.46 (5), p.37-41</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>288,314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17877326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, D.K</creatorcontrib><title>Study of two devices used to maintain normothermia in rats and mice during general anesthesia</title><title>Journal of the American Association for Laboratory Animal Science</title><addtitle>J Am Assoc Lab Animal Sci</addtitle><addtitle>J Am Assoc Lab Anim Sci</addtitle><description>Rodents are very susceptible to hypothermia during anesthetic events because of their high body surface-to-mass ratio. This study examined the effectiveness of 2 heating devices, a heatpad and a circulating hot-water blanket, during 60 min of isoflurane general anesthesia in rats and
mice (n = 6 per treatment). In addition, 1 control group of animals for each species was anesthetized with no heat source (n = 6). Both devices carried minimal risk of causing thermal burns or hyperthermia. Rats on the circulating water blanket showed a slight decrease (0.11 ± 0.19
°C) from the initial (time 0) body temperature (mean ± standard error), whereas the heatpad was associated with a significant increase (0.96 ± 0.10 °C). Mice on the circulating water blanket showed a significant decrease (0.46 ± 0.05 °C) in body temperature.
The trend in mice on the heatpad was similar to that in rats, with a significant increase (0.94 ± 0.13 °C) from the body temperature at time 0. Although statistically significant, these deviations from baseline body temperature were not considered physiologically relevant. In comparison,
body temperatures decreased significantly in rats and mice (4.42 ± 0.60 and 9.90 ± 0.35 °C, respectively) with no heat source. Both heating devices were safe and effective, but the low cost, ease of maintenance, and portability of the heatpad may make it a more desirable
choice in some facilities.</description><subject>anesthesia</subject><subject>Anesthesia, General - adverse effects</subject><subject>Animals</subject><subject>body temperature changes</subject><subject>Body Temperature Regulation</subject><subject>Equipment Design</subject><subject>equipment performance</subject><subject>Female</subject><subject>general anesthetics</subject><subject>Heating - instrumentation</subject><subject>heating systems</subject><subject>heatpad</subject><subject>hot-water blanket</subject><subject>hypothermia</subject><subject>Hypothermia - etiology</subject><subject>Hypothermia - prevention & control</subject><subject>Intraoperative Care</subject><subject>isoflurane</subject><subject>Laboratory Animal Science - instrumentation</subject><subject>Laboratory Animal Science - methods</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>veterinary equipment</subject><issn>1559-6109</issn><issn>2769-6677</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEokvhL4BP3FbyR_yRIypQkCr1UHpEo0nsLF4lcbGdovLrmbDLEUvWvLYfvTPjedbspDXd3hhrnzc7oTVpwbuL5lUpR8611Uq-bC6EddYqaXbN97u6-ieWRlZ_JebDYxxCYWsJntXEZoxLpc2WlOdUf4Q8R2R0zlgLw8WzmXjm1xyXAzuEJWSc6D4UYkvE182LEacS3pzjZXP_-dO3qy_7m9vrr1cfbvajMqbu5dj2wmBrde-sHJwnjUarcfAqKHT0qrX3wZsOHddGjwPvlAmeiF70nbps3p98H3L6uVJ2mGMZwjRRKWktYJzsJO8sgW_P4NrPwcNDjjPmJ_j3IQR8PAHUUKDe4ZjWvFDtgDhhgeMpSM4t8L-rNWfBNWCum9hsbv9jE4ez0zacbTbw2JpFk6MU3AkLQrQOfBhxnSpUzHD4DWVzfHdyHDEBHnIscH8nuVCcO961bav-ALdEmDE</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Taylor, D.K</creator><general>American Association for Laboratory Animal Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Study of two devices used to maintain normothermia in rats and mice during general anesthesia</title><author>Taylor, D.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f366t-2f4b16a475b872c8d6a4a653fcd3e3a84b155dded69a80565fc0936ed3fcb1b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>anesthesia</topic><topic>Anesthesia, General - adverse effects</topic><topic>Animals</topic><topic>body temperature changes</topic><topic>Body Temperature Regulation</topic><topic>Equipment Design</topic><topic>equipment performance</topic><topic>Female</topic><topic>general anesthetics</topic><topic>Heating - instrumentation</topic><topic>heating systems</topic><topic>heatpad</topic><topic>hot-water blanket</topic><topic>hypothermia</topic><topic>Hypothermia - etiology</topic><topic>Hypothermia - prevention & control</topic><topic>Intraoperative Care</topic><topic>isoflurane</topic><topic>Laboratory Animal Science - instrumentation</topic><topic>Laboratory Animal Science - methods</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>veterinary equipment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, D.K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Association for Laboratory Animal Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, D.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of two devices used to maintain normothermia in rats and mice during general anesthesia</atitle><jtitle>Journal of the American Association for Laboratory Animal Science</jtitle><stitle>J Am Assoc Lab Animal Sci</stitle><addtitle>J Am Assoc Lab Anim Sci</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>46</volume><issue>5</issue><spage>37</spage><epage>41</epage><pages>37-41</pages><issn>1559-6109</issn><eissn>2769-6677</eissn><abstract>Rodents are very susceptible to hypothermia during anesthetic events because of their high body surface-to-mass ratio. This study examined the effectiveness of 2 heating devices, a heatpad and a circulating hot-water blanket, during 60 min of isoflurane general anesthesia in rats and
mice (n = 6 per treatment). In addition, 1 control group of animals for each species was anesthetized with no heat source (n = 6). Both devices carried minimal risk of causing thermal burns or hyperthermia. Rats on the circulating water blanket showed a slight decrease (0.11 ± 0.19
°C) from the initial (time 0) body temperature (mean ± standard error), whereas the heatpad was associated with a significant increase (0.96 ± 0.10 °C). Mice on the circulating water blanket showed a significant decrease (0.46 ± 0.05 °C) in body temperature.
The trend in mice on the heatpad was similar to that in rats, with a significant increase (0.94 ± 0.13 °C) from the body temperature at time 0. Although statistically significant, these deviations from baseline body temperature were not considered physiologically relevant. In comparison,
body temperatures decreased significantly in rats and mice (4.42 ± 0.60 and 9.90 ± 0.35 °C, respectively) with no heat source. Both heating devices were safe and effective, but the low cost, ease of maintenance, and portability of the heatpad may make it a more desirable
choice in some facilities.</abstract><cop>United States</cop><pub>American Association for Laboratory Animal Science</pub><pmid>17877326</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1559-6109 |
| ispartof | Journal of the American Association for Laboratory Animal Science, 2007-09, Vol.46 (5), p.37-41 |
| issn | 1559-6109 2769-6677 |
| language | eng |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals |
| subjects | anesthesia Anesthesia, General - adverse effects Animals body temperature changes Body Temperature Regulation Equipment Design equipment performance Female general anesthetics Heating - instrumentation heating systems heatpad hot-water blanket hypothermia Hypothermia - etiology Hypothermia - prevention & control Intraoperative Care isoflurane Laboratory Animal Science - instrumentation Laboratory Animal Science - methods Male Mice Mice, Inbred Strains Rats Rats, Sprague-Dawley veterinary equipment |
| title | Study of two devices used to maintain normothermia in rats and mice during general anesthesia |
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