Oviduct-specific expression of two therapeutic proteins in transgenic hens

Recent advances in avian transgenesis have led to the possibility of utilizing the laying hen as a production platform for the large-scale synthesis of pharmaceutical proteins. Ovalbumin constitutes more than half of the protein in the white of a laid egg, and expression of the ovalbumin gene is res...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-02, Vol.104 (6), p.1771-1776
Hauptverfasser:	Lillico, S.G, Sherman, A, McGrew, M.J, Robertson, C.D, Smith, J, Haslam, C, Barnard, P, Radcliffe, P.A, Mitrophanous, K.A, Elliot, E.A, Sang, H.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological Sciences biopharmaceuticals Chickens Chickens - genetics Chickens - metabolism Egg Proteins - biosynthesis Egg Proteins - genetics Egg Proteins - therapeutic use Egg White - chemistry Eggs Equine infectious anemia virus Female gene expression gene transfer Genes genetic transformation Genetic Vectors hens Humans Infectious Anemia Virus, Equine - genetics Interferon beta-1a Interferon-beta - biosynthesis Interferon-beta - genetics Interferon-beta - physiology interferons Male Mice Ova ovalbumin Oviducts Oviducts - metabolism Plasmids Poultry promoter regions Proteins recombinant antibodies Recombinant proteins Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - secretion Regulatory sequences Transgenes Transgenic animals Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!