Gα₁₂ Specifically Regulates COX-2 Induction by Sphingosine 1-Phosphate: ROLE FOR JNK-DEPENDENT UBIQUITINATION AND DEGRADATION OF IκBα

Cyclooxygenase-2 (COX-2) plays a critical role in vasodilatation and local inflammatory responses during platelet aggregation and thrombosis. Sphingosine 1-phosphate (S1P), a sphingolipid released from activated platelets, stimulates COX-2 induction and activates G-protein-coupled receptors coupled...

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Veröffentlicht in:	The Journal of biological chemistry 2007-01, Vol.282 (3), p.1938-1947
Hauptverfasser:	Ki, Sung Hwan, Choi, Min Jung, Lee, Chang Ho, Kim, Sang Geon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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