The Effects of Alcohol on Folate Metabolism

The Effects of Alcohol on Folate Metabolism

Recent experiments in man and in animal models suggest that the acute toxicity of alcohol on folate metabolism is primarily related to its impact on the folate enterohepatic cycle. Alcohol blocks the release of folate from the hepatocyte, thereby disrupting folate supply to tissues and rapidly produ...

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Veröffentlicht in:Annual review of medicine 1982-01, Vol.33 (1), p.345-354
Hauptverfasser: Hillman, R S, Steinberg, S E
Format: Artikel
Sprache:eng
Schlagworte:
Alcoholism - complications
Animals
Biological Transport
Diet
Ethanol - pharmacology
Folic Acid - metabolism
Folic Acid - physiology
Folic Acid Deficiency - etiology
Haplorhini
Humans
Intestinal Absorption
Liver - metabolism
Tetrahydrofolates - metabolism
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Beschreibung
Zusammenfassung:Recent experiments in man and in animal models suggest that the acute toxicity of alcohol on folate metabolism is primarily related to its impact on the folate enterohepatic cycle. Alcohol blocks the release of folate from the hepatocyte, thereby disrupting folate supply to tissues and rapidly producing a defect in cell replication.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.me.33.020182.002021