Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes
Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. M...
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| Veröffentlicht in: | Taehan Suŭi Hakhoe chi 2009-12, Vol.49 (4) |
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| container_title | Taehan Suŭi Hakhoe chi |
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| creator | Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea Park, K.I., Gyeongsang National University, Jinju, Republic of Korea Park, H.S., Gyeongsang National University, Jinju, Republic of Korea Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea Kim, E.H., International University of Korea, Jinju, Republic of Korea Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea |
| description | Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats. |
| format | Article |
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This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.</description><identifier>ISSN: 1225-0198</identifier><language>eng</language><subject>BIFENILOS POLICLORADOS ; COX-2 ; cPLA2 ; PCB118 ; POLYCHLORINATED BIPHENYLS ; POLYCHLORURE DE BIPHENYLE ; proinflammatory effect</subject><ispartof>Taehan Suŭi Hakhoe chi, 2009-12, Vol.49 (4)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Park, K.I., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Park, H.S., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kim, E.H., International University of Korea, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><title>Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes</title><title>Taehan Suŭi Hakhoe chi</title><description>Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.</description><subject>BIFENILOS POLICLORADOS</subject><subject>COX-2</subject><subject>cPLA2</subject><subject>PCB118</subject><subject>POLYCHLORINATED BIPHENYLS</subject><subject>POLYCHLORURE DE BIPHENYLE</subject><subject>proinflammatory effect</subject><issn>1225-0198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0NDIy1TUwtLTgYOAtLs4yAAIzA0NTM0tOBnvXtLTU5BKF_DSFAGcnQ0MLhfw8hdSKgqLU4uJMIBMo7uwfoWukkJiXopAc4ONopJCZp1CUWKJQkloMRDwMrGmJOcWpvFCam0HWzTXE2UM3LTE_PjG9KLM43jvIyMAQaKWxgZm5MSF5ALeNL2c</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Park, K.I., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Park, H.S., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea</creator><creator>Kim, E.H., International University of Korea, Jinju, Republic of Korea</creator><creator>Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea</creator><scope>FBQ</scope></search><sort><creationdate>200912</creationdate><title>Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes</title><author>Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea ; Park, K.I., Gyeongsang National University, Jinju, Republic of Korea ; Park, H.S., Gyeongsang National University, Jinju, Republic of Korea ; Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea ; Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea ; Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea ; Kim, E.H., International University of Korea, Jinju, Republic of Korea ; Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-fao_agris_KR20100030673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>BIFENILOS POLICLORADOS</topic><topic>COX-2</topic><topic>cPLA2</topic><topic>PCB118</topic><topic>POLYCHLORINATED BIPHENYLS</topic><topic>POLYCHLORURE DE BIPHENYLE</topic><topic>proinflammatory effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Park, K.I., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Park, H.S., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kim, E.H., International University of Korea, Jinju, Republic of Korea</creatorcontrib><creatorcontrib>Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea</creatorcontrib><collection>AGRIS</collection><jtitle>Taehan Suŭi Hakhoe chi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, D.Y., Gyeongsang National University, Jinju, Republic of Korea</au><au>Park, K.I., Gyeongsang National University, Jinju, Republic of Korea</au><au>Park, H.S., Gyeongsang National University, Jinju, Republic of Korea</au><au>Kang, S.R., Gyeongsang National University, Jinju, Republic of Korea</au><au>Cho, J.H., Gyeongsang National University, Jinju, Republic of Korea</au><au>Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea</au><au>Kim, E.H., International University of Korea, Jinju, Republic of Korea</au><au>Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes</atitle><jtitle>Taehan Suŭi Hakhoe chi</jtitle><date>2009-12</date><risdate>2009</risdate><volume>49</volume><issue>4</issue><issn>1225-0198</issn><abstract>Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.</abstract></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | BIFENILOS POLICLORADOS COX-2 cPLA2 PCB118 POLYCHLORINATED BIPHENYLS POLYCHLORURE DE BIPHENYLE proinflammatory effect |
| title | Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes |
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