Biological Activity of Flavonoids Isolated from Aster tataricus L

In an ongoing investigation into anti-oxidative compounds from natural products, the EtOAc soluble fraction of Aster tataricus L. (Compositae) showed significant anti-oxidative activity on the NBT superoxide scavenging assay. By means of an activity-guided purification, three flavonoids, kaempferol (1), quercetin (2), astragalin (3) and one monoterpene glycoside, shionoside A (4) were isolated. Their structures were determined spectral analyses. Compounds 2 and 3 showed potent antioxidative activity, while, compounds 1 and 4 were inactive (IC∧50 greater than 120 ㎍/mL). In addition, these compounds were examined for the effect of interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cell. Compounds 1-3 showed negligible inhibitory activity against IL-6 production in TNF-α stimulated MG-63 cell, and compound 4 was inactive.