Isolation of 5α-reductase Inhibitors from Euphorbia jolkinii

Isolation of 5α-reductase Inhibitors from Euphorbia jolkinii

Twenty eight comopounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory ef...

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Veröffentlicht in:Korean Journal of Pharmacognosy 2005-03, Vol.36 (1)
Hauptverfasser: Park, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), Kim, J.A. (Yeungnam University, Kyoungsan, Republic of Korea), Hua, Xu Guang (Yeungnam University, Kyoungsan, Republic of Korea), Lee, C.G. (Yeungnam University, Kyoungsan, Republic of Korea), Choi, J.Y. (Yeungnam University, Kyoungsan, Republic of Korea), Oh, I.S. (Yeungnam University, Kyoungsan, Republic of Korea), Son, A.R. (Yeungnam University, Kyoungsan, Republic of Korea), Chung, S.R. (Yeungnam University, Kyoungsan, Republic of Korea), Lee, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), E-mail: seungho@yu.ac.kr
Format: Artikel
Sprache:kor
Schlagworte:
5apha-reductase inhibitor
Euphorbia jolkinii
EUPHORBIACEAE
hydrolysable tannin
male pattern alopecia
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Zusammenfassung:Twenty eight comopounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.
ISSN:0253-3073