Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents
This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1%...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-09, Vol.72 (9), p.2377-2384 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Lin. L.W.(Hungkuang Univ. Taiwan) Chen, H.Y Wu, C.R Liao, P.M Lin, Y.T Hsieh, M.T Ching, H |
| description | This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1-2 h. Furthermore, the BP radix reduced the abdominal Evan's blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and anti-inflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide. |
| doi_str_mv | 10.1271/bbb.80276 |
| format | Article |
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L.W.(Hungkuang Univ. Taiwan) ; Chen, H.Y ; Wu, C.R ; Liao, P.M ; Lin, Y.T ; Hsieh, M.T ; Ching, H</creator><creatorcontrib>Lin. L.W.(Hungkuang Univ. Taiwan) ; Chen, H.Y ; Wu, C.R ; Liao, P.M ; Lin, Y.T ; Hsieh, M.T ; Ching, H</creatorcontrib><description>This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1-2 h. Furthermore, the BP radix reduced the abdominal Evan's blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and anti-inflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.80276</identifier><identifier>PMID: 18776680</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ANALGESICOS ; ANALGESICS ; Analgesics - adverse effects ; Analgesics - pharmacology ; Analgesics - therapeutic use ; ANALGESIQUE ; Animals ; ANTI-INFLAMMATOIRE ; anti-inflammatory activity ; Anti-Inflammatory Agents - adverse effects ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; ANTIINFLAMMATORY AGENTS ; ANTINFLAMATORIOS ; antinociceptive activity ; Biological and medical sciences ; Broussonetia ; BROUSSONETIA PAPYRIFERA ; Capillary Permeability - drug effects ; Carrageenan ; Dose-Response Relationship, Drug ; DRUG PLANTS ; Edema - chemically induced ; Edema - drug therapy ; Fruit ; Fundamental and applied biological sciences. Psychology ; Male ; Mice ; Mice, Inbred ICR ; Pain - chemically induced ; Pain - drug therapy ; Pain Measurement - drug effects ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Plant Roots ; PLANTAS MEDICINALES ; PLANTE MEDICINALE ; RACINE ; RAICES ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; ROOTS ; TRITERPENOIDE ; TRITERPENOIDOS ; TRITERPENOIDS ; vascular permeability</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2008-09, Vol.72 (9), p.2377-2384</ispartof><rights>2008 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-14e78cade3bf712ec05e660c70d273134ca6c242a89a63cc0011398171d0adcf3</citedby><cites>FETCH-LOGICAL-c432t-14e78cade3bf712ec05e660c70d273134ca6c242a89a63cc0011398171d0adcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20804633$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18776680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin. L.W.(Hungkuang Univ. Taiwan)</creatorcontrib><creatorcontrib>Chen, H.Y</creatorcontrib><creatorcontrib>Wu, C.R</creatorcontrib><creatorcontrib>Liao, P.M</creatorcontrib><creatorcontrib>Lin, Y.T</creatorcontrib><creatorcontrib>Hsieh, M.T</creatorcontrib><creatorcontrib>Ching, H</creatorcontrib><title>Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1-2 h. Furthermore, the BP radix reduced the abdominal Evan's blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and anti-inflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide.</description><subject>ANALGESICOS</subject><subject>ANALGESICS</subject><subject>Analgesics - adverse effects</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>ANALGESIQUE</subject><subject>Animals</subject><subject>ANTI-INFLAMMATOIRE</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>ANTIINFLAMMATORY AGENTS</subject><subject>ANTINFLAMATORIOS</subject><subject>antinociceptive activity</subject><subject>Biological and medical sciences</subject><subject>Broussonetia</subject><subject>BROUSSONETIA PAPYRIFERA</subject><subject>Capillary Permeability - drug effects</subject><subject>Carrageenan</subject><subject>Dose-Response Relationship, Drug</subject><subject>DRUG PLANTS</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Fruit</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Pain - chemically induced</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement - drug effects</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Plant Roots</subject><subject>PLANTAS MEDICINALES</subject><subject>PLANTE MEDICINALE</subject><subject>RACINE</subject><subject>RAICES</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>ROOTS</subject><subject>TRITERPENOIDE</subject><subject>TRITERPENOIDOS</subject><subject>TRITERPENOIDS</subject><subject>vascular permeability</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v1DAQxS0EokvhwAcAWUIcOKT4X2znCCtaQJXgAGdr4jjUVRIH29tqL3x2pt0FLpys9-Y3M_IbQp5zdsaF4W_7vj-zTBj9gGy4VKbRnTIPyYZ1XDdWtfyEPCnlmjE0Wv6YnHBrjNaWbcivbZpXyLGkhd7GekVvUKRdoWjWQtNI32eUWA41ArrrPscxZKBQaE20XgUKS41L8tGHtcabOz3ce01cxgnmGWrKewoei7HGUGhcaE5DWGp5Sh6NMJXw7Pieku_nH75tPzaXXy4-bd9dNl5JURuugrEehiD70XARPGuD1swbNggj8csetBdKgO1AS-8Z41x2lhs-MBj8KE_Jq8PcNaefu1Cqu067vOBKx5XqrGJcW6TeHCifUyk5jG7NcYa8d5y5u6QdJu3uk0b25XHirp_D8I88RovA6yMAxcM0Zlh8LH85wSxTWkrk1IHDtFKe4TblaXAV9lPKf5rk__a_OLSNkBz8wAu6z18FXhiv3LZS_gbCZKMJ</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Lin. L.W.(Hungkuang Univ. Taiwan)</creator><creator>Chen, H.Y</creator><creator>Wu, C.R</creator><creator>Liao, P.M</creator><creator>Lin, Y.T</creator><creator>Hsieh, M.T</creator><creator>Ching, H</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20080901</creationdate><title>Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents</title><author>Lin. L.W.(Hungkuang Univ. Taiwan) ; Chen, H.Y ; Wu, C.R ; Liao, P.M ; Lin, Y.T ; Hsieh, M.T ; Ching, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-14e78cade3bf712ec05e660c70d273134ca6c242a89a63cc0011398171d0adcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ANALGESICOS</topic><topic>ANALGESICS</topic><topic>Analgesics - adverse effects</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>ANALGESIQUE</topic><topic>Animals</topic><topic>ANTI-INFLAMMATOIRE</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - adverse effects</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>ANTIINFLAMMATORY AGENTS</topic><topic>ANTINFLAMATORIOS</topic><topic>antinociceptive activity</topic><topic>Biological and medical sciences</topic><topic>Broussonetia</topic><topic>BROUSSONETIA PAPYRIFERA</topic><topic>Capillary Permeability - drug effects</topic><topic>Carrageenan</topic><topic>Dose-Response Relationship, Drug</topic><topic>DRUG PLANTS</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Fruit</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Pain - chemically induced</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement - drug effects</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Plant Roots</topic><topic>PLANTAS MEDICINALES</topic><topic>PLANTE MEDICINALE</topic><topic>RACINE</topic><topic>RAICES</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>ROOTS</topic><topic>TRITERPENOIDE</topic><topic>TRITERPENOIDOS</topic><topic>TRITERPENOIDS</topic><topic>vascular permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin. L.W.(Hungkuang Univ. Taiwan)</creatorcontrib><creatorcontrib>Chen, H.Y</creatorcontrib><creatorcontrib>Wu, C.R</creatorcontrib><creatorcontrib>Liao, P.M</creatorcontrib><creatorcontrib>Lin, Y.T</creatorcontrib><creatorcontrib>Hsieh, M.T</creatorcontrib><creatorcontrib>Ching, H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin. L.W.(Hungkuang Univ. Taiwan)</au><au>Chen, H.Y</au><au>Wu, C.R</au><au>Liao, P.M</au><au>Lin, Y.T</au><au>Hsieh, M.T</au><au>Ching, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>72</volume><issue>9</issue><spage>2377</spage><epage>2384</epage><pages>2377-2384</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1-2 h. Furthermore, the BP radix reduced the abdominal Evan's blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and anti-inflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>18776680</pmid><doi>10.1271/bbb.80276</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2008-09, Vol.72 (9), p.2377-2384 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_fao_agris_JP2009000553 |
| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | ANALGESICOS ANALGESICS Analgesics - adverse effects Analgesics - pharmacology Analgesics - therapeutic use ANALGESIQUE Animals ANTI-INFLAMMATOIRE anti-inflammatory activity Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use ANTIINFLAMMATORY AGENTS ANTINFLAMATORIOS antinociceptive activity Biological and medical sciences Broussonetia BROUSSONETIA PAPYRIFERA Capillary Permeability - drug effects Carrageenan Dose-Response Relationship, Drug DRUG PLANTS Edema - chemically induced Edema - drug therapy Fruit Fundamental and applied biological sciences. Psychology Male Mice Mice, Inbred ICR Pain - chemically induced Pain - drug therapy Pain Measurement - drug effects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Plant Roots PLANTAS MEDICINALES PLANTE MEDICINALE RACINE RAICES RAT RATA RATS Rats, Sprague-Dawley ROOTS TRITERPENOIDE TRITERPENOIDOS TRITERPENOIDS vascular permeability |
| title | Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents |
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