Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells

Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-12, Vol.71 (12), p.2886-2892
Hauptverfasser:	Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.)), Kim, E.Y, Moon, P.D, Um, J.Y, Kim, H.M, Lee, H.S, Sohn, Y, Park, S.K, Jung, H.S, Sohn, N.W
Format:	Artikel
Sprache:	eng
Schlagworte:	ALERGENOS ALLERGENE ALLERGENS ANAPHYLACTIC REACTIONS Anaphylaxis - prevention & control Animals Anti-Allergic Agents - pharmacology Biological and medical sciences Cells, Cultured CELULAS FIBROSAS CITOQUINAS CYTOKINE CYTOKINES Cytokines - biosynthesis FITOTERAPIA Fundamental and applied biological sciences. Psychology HISTAMINA HISTAMINE Histamine - biosynthesis Histamine Release - drug effects HMC-1 cell I-kappa B Proteins - metabolism IMMUNOBLOTTING Immunoglobulin E - immunology Lithospermi radix Lithospermum - chemistry LITHOSPERMUM ERYTHRORHIZON MAST CELLS Mast Cells - drug effects Mast Cells - metabolism MASTOCYTE NF-kappa B - metabolism NF-KappaB Inhibitor alpha nuclear factor-kappa B (NF-κB) p-Methoxy-N-methylphenethylamine - pharmacology passive cutaneous anaphylaxis PHYTOTHERAPIE PHYTOTHERAPY Plant Extracts - pharmacology Rats Rats, Sprague-Dawley REACCIONES ANAFILACTICAS REACTION ANAPHYLACTIQUE
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