Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells
Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-12, Vol.71 (12), p.2886-2892 |
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| creator | Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.)) Kim, E.Y Moon, P.D Um, J.Y Kim, H.M Lee, H.S Sohn, Y Park, S.K Jung, H.S Sohn, N.W |
| description | Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-kappaB) activation and IkappaB-alpha degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases. |
| doi_str_mv | 10.1271/bbb.70208 |
| format | Article |
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This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-kappaB) activation and IkappaB-alpha degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.70208</identifier><identifier>PMID: 18071264</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ALERGENOS ; ALLERGENE ; ALLERGENS ; ANAPHYLACTIC REACTIONS ; Anaphylaxis - prevention & control ; Animals ; Anti-Allergic Agents - pharmacology ; Biological and medical sciences ; Cells, Cultured ; CELULAS FIBROSAS ; CITOQUINAS ; CYTOKINE ; CYTOKINES ; Cytokines - biosynthesis ; FITOTERAPIA ; Fundamental and applied biological sciences. Psychology ; HISTAMINA ; HISTAMINE ; Histamine - biosynthesis ; Histamine Release - drug effects ; HMC-1 cell ; I-kappa B Proteins - metabolism ; IMMUNOBLOTTING ; Immunoglobulin E - immunology ; Lithospermi radix ; Lithospermum - chemistry ; LITHOSPERMUM ERYTHRORHIZON ; MAST CELLS ; Mast Cells - drug effects ; Mast Cells - metabolism ; MASTOCYTE ; NF-kappa B - metabolism ; NF-KappaB Inhibitor alpha ; nuclear factor-kappa B (NF-κB) ; p-Methoxy-N-methylphenethylamine - pharmacology ; passive cutaneous anaphylaxis ; PHYTOTHERAPIE ; PHYTOTHERAPY ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; REACCIONES ANAFILACTICAS ; REACTION ANAPHYLACTIQUE</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2007-12, Vol.71 (12), p.2886-2892</ispartof><rights>2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2007</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-3c463d705939d47df8161816f3c075345b6e72ef19f04c2429d2ac8fa7a381983</citedby><cites>FETCH-LOGICAL-c589t-3c463d705939d47df8161816f3c075345b6e72ef19f04c2429d2ac8fa7a381983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20043065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18071264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.))</creatorcontrib><creatorcontrib>Kim, E.Y</creatorcontrib><creatorcontrib>Moon, P.D</creatorcontrib><creatorcontrib>Um, J.Y</creatorcontrib><creatorcontrib>Kim, H.M</creatorcontrib><creatorcontrib>Lee, H.S</creatorcontrib><creatorcontrib>Sohn, Y</creatorcontrib><creatorcontrib>Park, S.K</creatorcontrib><creatorcontrib>Jung, H.S</creatorcontrib><creatorcontrib>Sohn, N.W</creatorcontrib><title>Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-kappaB) activation and IkappaB-alpha degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.</description><subject>ALERGENOS</subject><subject>ALLERGENE</subject><subject>ALLERGENS</subject><subject>ANAPHYLACTIC REACTIONS</subject><subject>Anaphylaxis - prevention & control</subject><subject>Animals</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>CELULAS FIBROSAS</subject><subject>CITOQUINAS</subject><subject>CYTOKINE</subject><subject>CYTOKINES</subject><subject>Cytokines - biosynthesis</subject><subject>FITOTERAPIA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HISTAMINA</subject><subject>HISTAMINE</subject><subject>Histamine - biosynthesis</subject><subject>Histamine Release - drug effects</subject><subject>HMC-1 cell</subject><subject>I-kappa B Proteins - metabolism</subject><subject>IMMUNOBLOTTING</subject><subject>Immunoglobulin E - immunology</subject><subject>Lithospermi radix</subject><subject>Lithospermum - chemistry</subject><subject>LITHOSPERMUM ERYTHRORHIZON</subject><subject>MAST CELLS</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>MASTOCYTE</subject><subject>NF-kappa B - metabolism</subject><subject>NF-KappaB Inhibitor alpha</subject><subject>nuclear factor-kappa B (NF-κB)</subject><subject>p-Methoxy-N-methylphenethylamine - pharmacology</subject><subject>passive cutaneous anaphylaxis</subject><subject>PHYTOTHERAPIE</subject><subject>PHYTOTHERAPY</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>REACCIONES ANAFILACTICAS</subject><subject>REACTION ANAPHYLACTIQUE</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V2rFCEYB3CJorOduugDFEIUdLEnn9EZ9TIOvbJQF3Utzzjaus2Mmzp09tvntltBBF2IIL_nRf6EPAR2BY2EF33fX0nWMHWLrIALue60kLfJimno1kq0cEHu5bxjrD60cJdcgGISmk6syG4TyjbmvUtToAmHcEPdTUloCw3zNvShZLoNueAUZkeTGx1mR3Ee6D7FYbElxJlGX7EfcZqwxHSg9lDi16MPM50wF2rdOOb75I7HMbsH5_uSfH796tP12_Xmw5t31y83a9sqXdbcio4PkrWa60HIwSvooB7PLZMtF23fOdk4D9ozYRvR6KFBqzxK5Aq04pfk2alv3fDb4nIxU8jHDXB2ccmm00xxIf4PG9ZKAC0qfPIX3MUlzfUTBoTQdTnetlU9PymbYs7JebNPYcJ0MMDMMSdTczI_c6r28bnj0k9u-CPPwVTw9AwwWxx9wtmG_Ns1jAnOuuNQcXI1gJgm_B7TOJiChzGmX0X8X_Mfnco8RoNfUlXvP9amijEQoPkPA3i1Dw</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.))</creator><creator>Kim, E.Y</creator><creator>Moon, P.D</creator><creator>Um, J.Y</creator><creator>Kim, H.M</creator><creator>Lee, H.S</creator><creator>Sohn, Y</creator><creator>Park, S.K</creator><creator>Jung, H.S</creator><creator>Sohn, N.W</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells</title><author>Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.)) ; Kim, E.Y ; Moon, P.D ; Um, J.Y ; Kim, H.M ; Lee, H.S ; Sohn, Y ; Park, S.K ; Jung, H.S ; Sohn, N.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-3c463d705939d47df8161816f3c075345b6e72ef19f04c2429d2ac8fa7a381983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>ALERGENOS</topic><topic>ALLERGENE</topic><topic>ALLERGENS</topic><topic>ANAPHYLACTIC REACTIONS</topic><topic>Anaphylaxis - prevention & control</topic><topic>Animals</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>CELULAS FIBROSAS</topic><topic>CITOQUINAS</topic><topic>CYTOKINE</topic><topic>CYTOKINES</topic><topic>Cytokines - biosynthesis</topic><topic>FITOTERAPIA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HISTAMINA</topic><topic>HISTAMINE</topic><topic>Histamine - biosynthesis</topic><topic>Histamine Release - drug effects</topic><topic>HMC-1 cell</topic><topic>I-kappa B Proteins - metabolism</topic><topic>IMMUNOBLOTTING</topic><topic>Immunoglobulin E - immunology</topic><topic>Lithospermi radix</topic><topic>Lithospermum - chemistry</topic><topic>LITHOSPERMUM ERYTHRORHIZON</topic><topic>MAST CELLS</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>MASTOCYTE</topic><topic>NF-kappa B - metabolism</topic><topic>NF-KappaB Inhibitor alpha</topic><topic>nuclear factor-kappa B (NF-κB)</topic><topic>p-Methoxy-N-methylphenethylamine - pharmacology</topic><topic>passive cutaneous anaphylaxis</topic><topic>PHYTOTHERAPIE</topic><topic>PHYTOTHERAPY</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>REACCIONES ANAFILACTICAS</topic><topic>REACTION ANAPHYLACTIQUE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.))</creatorcontrib><creatorcontrib>Kim, E.Y</creatorcontrib><creatorcontrib>Moon, P.D</creatorcontrib><creatorcontrib>Um, J.Y</creatorcontrib><creatorcontrib>Kim, H.M</creatorcontrib><creatorcontrib>Lee, H.S</creatorcontrib><creatorcontrib>Sohn, Y</creatorcontrib><creatorcontrib>Park, S.K</creatorcontrib><creatorcontrib>Jung, H.S</creatorcontrib><creatorcontrib>Sohn, N.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, E.K.(Kyung Hee Univ., Seoul (Korea R.))</au><au>Kim, E.Y</au><au>Moon, P.D</au><au>Um, J.Y</au><au>Kim, H.M</au><au>Lee, H.S</au><au>Sohn, Y</au><au>Park, S.K</au><au>Jung, H.S</au><au>Sohn, N.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>71</volume><issue>12</issue><spage>2886</spage><epage>2892</epage><pages>2886-2892</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-kappaB) activation and IkappaB-alpha degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>18071264</pmid><doi>10.1271/bbb.70208</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2007-12, Vol.71 (12), p.2886-2892 |
| issn | 0916-8451 1347-6947 |
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| recordid | cdi_fao_agris_JP2008001419 |
| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | ALERGENOS ALLERGENE ALLERGENS ANAPHYLACTIC REACTIONS Anaphylaxis - prevention & control Animals Anti-Allergic Agents - pharmacology Biological and medical sciences Cells, Cultured CELULAS FIBROSAS CITOQUINAS CYTOKINE CYTOKINES Cytokines - biosynthesis FITOTERAPIA Fundamental and applied biological sciences. Psychology HISTAMINA HISTAMINE Histamine - biosynthesis Histamine Release - drug effects HMC-1 cell I-kappa B Proteins - metabolism IMMUNOBLOTTING Immunoglobulin E - immunology Lithospermi radix Lithospermum - chemistry LITHOSPERMUM ERYTHRORHIZON MAST CELLS Mast Cells - drug effects Mast Cells - metabolism MASTOCYTE NF-kappa B - metabolism NF-KappaB Inhibitor alpha nuclear factor-kappa B (NF-κB) p-Methoxy-N-methylphenethylamine - pharmacology passive cutaneous anaphylaxis PHYTOTHERAPIE PHYTOTHERAPY Plant Extracts - pharmacology Rats Rats, Sprague-Dawley REACCIONES ANAFILACTICAS REACTION ANAPHYLACTIQUE |
| title | Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells |
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