Bioavailability of glucosyl hesperidin in rats
Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronid...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006-06, Vol.70 (6), p.1386-1394 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Yamada, M.(Hayashibara Biochemical Labs. Inc., Okayama (Japan)) Tanabe, F Arai, N Mitsuzumi, H Miwa, Y Kubota, M Chaen, H Kibata, M |
| description | Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility. |
| doi_str_mv | 10.1271/bbb.50657 |
| format | Article |
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Inc., Okayama (Japan)) ; Tanabe, F ; Arai, N ; Mitsuzumi, H ; Miwa, Y ; Kubota, M ; Chaen, H ; Kibata, M</creator><creatorcontrib>Yamada, M.(Hayashibara Biochemical Labs. Inc., Okayama (Japan)) ; Tanabe, F ; Arai, N ; Mitsuzumi, H ; Miwa, Y ; Kubota, M ; Chaen, H ; Kibata, M</creatorcontrib><description>Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.50657</identifier><identifier>PMID: 16794318</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Administration, Oral ; Animals ; BIOAVAILABILITY ; BIODISPONIBILIDAD ; BIODISPONIBILITE ; Biological and medical sciences ; Biological Availability ; Cecum - drug effects ; Cecum - metabolism ; Chromatography, High Pressure Liquid ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; Fundamental and applied biological sciences. Psychology ; GLUCOSIDE ; GLUCOSIDES ; Glucosides - administration & dosage ; Glucosides - blood ; Glucosides - pharmacokinetics ; Glucosides - urine ; GLUCOSIDOS ; glucosyl hesperidin ; Glucuronic Acid - blood ; hesperetin conjugates ; hesperidin ; Hesperidin - administration & dosage ; Hesperidin - analogs & derivatives ; Hesperidin - blood ; Hesperidin - pharmacokinetics ; Hesperidin - urine ; Hydrolysis ; intestinal bacteria ; Intestine, Small - drug effects ; Intestine, Small - metabolism ; Male ; Molecular Structure ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2006-06, Vol.70 (6), p.1386-1394</ispartof><rights>2006 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-7877dead85f414471afc3953485c6a4cecdda2a2ce4571560cbb85122b9bb7f63</citedby><cites>FETCH-LOGICAL-c659t-7877dead85f414471afc3953485c6a4cecdda2a2ce4571560cbb85122b9bb7f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18066994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16794318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, M.(Hayashibara Biochemical Labs. Inc., Okayama (Japan))</creatorcontrib><creatorcontrib>Tanabe, F</creatorcontrib><creatorcontrib>Arai, N</creatorcontrib><creatorcontrib>Mitsuzumi, H</creatorcontrib><creatorcontrib>Miwa, Y</creatorcontrib><creatorcontrib>Kubota, M</creatorcontrib><creatorcontrib>Chaen, H</creatorcontrib><creatorcontrib>Kibata, M</creatorcontrib><title>Bioavailability of glucosyl hesperidin in rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>BIOAVAILABILITY</subject><subject>BIODISPONIBILIDAD</subject><subject>BIODISPONIBILITE</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cecum - drug effects</subject><subject>Cecum - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>FLAVONOIDE</subject><subject>FLAVONOIDES</subject><subject>FLAVONOIDS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCOSIDE</subject><subject>GLUCOSIDES</subject><subject>Glucosides - administration & dosage</subject><subject>Glucosides - blood</subject><subject>Glucosides - pharmacokinetics</subject><subject>Glucosides - urine</subject><subject>GLUCOSIDOS</subject><subject>glucosyl hesperidin</subject><subject>Glucuronic Acid - blood</subject><subject>hesperetin conjugates</subject><subject>hesperidin</subject><subject>Hesperidin - administration & dosage</subject><subject>Hesperidin - analogs & derivatives</subject><subject>Hesperidin - blood</subject><subject>Hesperidin - pharmacokinetics</subject><subject>Hesperidin - urine</subject><subject>Hydrolysis</subject><subject>intestinal bacteria</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - metabolism</subject><subject>Male</subject><subject>Molecular Structure</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0N9LHDEQB_AgLXqePvgHKAdFoQ97Jrv5tY_1UNsi6IM-h0k20Uhucya7LfffG70ToRQGAsNnZsIXoSOC56QW5FxrPWeYM7GDJqShouItFV_QBLeEV5Iysof2c37GuDQY2UV7hIuWNkRO0PzCR_gDPoD2wQ_rWXSzxzCamNdh9mTzyibf-X5WKsGQD9BXByHbw-07RQ9Xl_eLn9XN7fWvxY-bynDWDpWQQnQWOskcJZQKAs40LWuoZIYDNdZ0HdRQG0uZIIxjo7VkpK51q7VwvJmis83eVYovo82DWvpsbAjQ2zhmxSXjUpA3-O0f-BzH1Je_qXK4lSWOmhT1faNMijkn69Qq-SWktSJYvUWoSoTqPcJiT7YbR7203afcZlbA6RZANhBcgt74_Okk5rwtdIroxvnexbSEvzGFTg2wDjF9DDX_u3-8GXMQFTymon7f1RgLjBtey-YVLDySDg</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Yamada, M.(Hayashibara Biochemical Labs. 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Inc., Okayama (Japan)) ; Tanabe, F ; Arai, N ; Mitsuzumi, H ; Miwa, Y ; Kubota, M ; Chaen, H ; Kibata, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-7877dead85f414471afc3953485c6a4cecdda2a2ce4571560cbb85122b9bb7f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>BIOAVAILABILITY</topic><topic>BIODISPONIBILIDAD</topic><topic>BIODISPONIBILITE</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cecum - drug effects</topic><topic>Cecum - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>FLAVONOIDE</topic><topic>FLAVONOIDES</topic><topic>FLAVONOIDS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCOSIDE</topic><topic>GLUCOSIDES</topic><topic>Glucosides - administration & dosage</topic><topic>Glucosides - blood</topic><topic>Glucosides - pharmacokinetics</topic><topic>Glucosides - urine</topic><topic>GLUCOSIDOS</topic><topic>glucosyl hesperidin</topic><topic>Glucuronic Acid - blood</topic><topic>hesperetin conjugates</topic><topic>hesperidin</topic><topic>Hesperidin - administration & dosage</topic><topic>Hesperidin - analogs & derivatives</topic><topic>Hesperidin - blood</topic><topic>Hesperidin - pharmacokinetics</topic><topic>Hesperidin - urine</topic><topic>Hydrolysis</topic><topic>intestinal bacteria</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - metabolism</topic><topic>Male</topic><topic>Molecular Structure</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, M.(Hayashibara Biochemical Labs. Inc., Okayama (Japan))</creatorcontrib><creatorcontrib>Tanabe, F</creatorcontrib><creatorcontrib>Arai, N</creatorcontrib><creatorcontrib>Mitsuzumi, H</creatorcontrib><creatorcontrib>Miwa, Y</creatorcontrib><creatorcontrib>Kubota, M</creatorcontrib><creatorcontrib>Chaen, H</creatorcontrib><creatorcontrib>Kibata, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, M.(Hayashibara Biochemical Labs. Inc., Okayama (Japan))</au><au>Tanabe, F</au><au>Arai, N</au><au>Mitsuzumi, H</au><au>Miwa, Y</au><au>Kubota, M</au><au>Chaen, H</au><au>Kibata, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioavailability of glucosyl hesperidin in rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>70</volume><issue>6</issue><spage>1386</spage><epage>1394</epage><pages>1386-1394</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>16794318</pmid><doi>10.1271/bbb.50657</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2006-06, Vol.70 (6), p.1386-1394 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_fao_agris_JP2007003628 |
| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Administration, Oral Animals BIOAVAILABILITY BIODISPONIBILIDAD BIODISPONIBILITE Biological and medical sciences Biological Availability Cecum - drug effects Cecum - metabolism Chromatography, High Pressure Liquid FLAVONOIDE FLAVONOIDES FLAVONOIDS Fundamental and applied biological sciences. Psychology GLUCOSIDE GLUCOSIDES Glucosides - administration & dosage Glucosides - blood Glucosides - pharmacokinetics Glucosides - urine GLUCOSIDOS glucosyl hesperidin Glucuronic Acid - blood hesperetin conjugates hesperidin Hesperidin - administration & dosage Hesperidin - analogs & derivatives Hesperidin - blood Hesperidin - pharmacokinetics Hesperidin - urine Hydrolysis intestinal bacteria Intestine, Small - drug effects Intestine, Small - metabolism Male Molecular Structure RAT RATA RATS Rats, Sprague-Dawley |
| title | Bioavailability of glucosyl hesperidin in rats |
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