Design of a highly potent anti-hypertensive peptide based on ovokinin(2-7)

Ovokinin(2-7) (RADHPF), an orally active anti-hypertensive peptide derived from ovalbumin, lowers blood pressure in SHRs at a dose of 10 mg/kg. Attempts were made to potentiate its anti-hypertensive activity by replacing the amino acid residues in [Pro sup(2), Phe sup(3)]-ovokinin(2-7), which was pr...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-06, Vol.66 (6), p.1213-1217
Hauptverfasser:	Yamada, Y. (Kyoto Univ. (Japan)), Matoba, N, Usui, H, Onishi, K, Yoshikawa, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amino Acid Sequence Animals anti-hypertensive Antihypertensive agents Antihypertensive Agents - administration & dosage Antihypertensive Agents - chemistry Antihypertensive Agents - metabolism Antihypertensive Agents - pharmacology Biological and medical sciences BLOOD PRESSURE Blood Pressure - drug effects CARDIOVASCULAR AGENTS Cardiovascular system Dose-Response Relationship, Drug Drug Design HYPERTENSION Injections, Intravenous Male Medical sciences Ovalbumin - chemistry ovokinin(2-7) Pancreatin - metabolism Peptide Fragments - chemistry PEPTIDES Pharmacology. Drug treatments RATS Rats, Inbred SHR Rats, Inbred WKY spontaneously hypertensive rat (SHR) Time Factors
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