Purification of soluble beta-glucan with immune-enhancing activity from the cell wall of yeast [Saccharomyces cerevisiae]

β-Glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions, especially by activating macrophages. However, a major obstacle to the clinical application of β-(1→3)-glucan is its low solubility in aqueous media. In this study, soluble β-gluc...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-04, Vol.65 (4), p.837-841
Hauptverfasser:	Lee, J.N.(Korea Univ., Seoul (Korea R.)), Lee, D.Y, Ji, I.H, Kim, G.E, Kim, H.N, Sohn, J, Kim, S, Kim, C.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - isolation & purification Adjuvants, Immunologic - pharmacology Animals b-Glucan Biological and medical sciences Biotechnology Cell Wall - chemistry CELL WALLS Cells, Cultured Chromatography, Affinity Chromatography, High Pressure Liquid DEAE-Cellulose Fundamental and applied biological sciences. Psychology GLUCANS Glucans - administration & dosage Glucans - isolation & purification Glucans - pharmacology Health. Pharmaceutical industry IMMUNITY In Vitro Techniques Industrial applications and implications. Economical aspects Injections, Intravenous macrophage function MACROPHAGES Macrophages - drug effects Macrophages - immunology mannoprotein Mice Other active biomolecules PHAGOCYTES phagocytosis Phagocytosis - drug effects Polysaccharides - chemistry Production of active biomolecules PURIFICATION SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - chemistry TNF-α Tumor Necrosis Factor-alpha - biosynthesis β-glucan
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