Effect of IGF-Ⅰon expression of five related hair follicles in varied sheepskins
为探讨外源性IGF-Ⅰ对绵羊皮肤中毛囊生长调控的影响。选取36只新疆细毛羊，随机分成6组。在每只绵羊的左、右两侧肩胛前部分别进行拔毛、剃毛处理。同时在左侧肩胛前部的拔毛、剃毛和正常区的交叉处注射0.5ml IGF-Ⅰ（10ngand#8226;ml-1），然后在第0、3、6、9、12、50天采取皮样。用RT-PCR方法，测定各皮肤中GHR、IGF-Ⅰ、IGF-ⅠR、KAP3.2和KAP6-1的mRNA相对丰度。（1）IGF-Ⅰ可以下调正常皮肤中GHR基因的表达，对IGF-Ⅰ、IGF-ⅠR的表达没有显著的影响，能显著提高KAP3.2和KAP6-1的转录水平；（2）IGF-Ⅰ在3 d内可降低拔毛皮...
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| Veröffentlicht in: | Chung-kuo nung yeh kʿo hsüeh 2007-03, Vol.40 (3) |
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| creator | Li Yan Liao Herong Li Zhimian |
| description | 为探讨外源性IGF-Ⅰ对绵羊皮肤中毛囊生长调控的影响。选取36只新疆细毛羊，随机分成6组。在每只绵羊的左、右两侧肩胛前部分别进行拔毛、剃毛处理。同时在左侧肩胛前部的拔毛、剃毛和正常区的交叉处注射0.5ml IGF-Ⅰ（10ngand#8226;ml-1），然后在第0、3、6、9、12、50天采取皮样。用RT-PCR方法，测定各皮肤中GHR、IGF-Ⅰ、IGF-ⅠR、KAP3.2和KAP6-1的mRNA相对丰度。（1）IGF-Ⅰ可以下调正常皮肤中GHR基因的表达，对IGF-Ⅰ、IGF-ⅠR的表达没有显著的影响，能显著提高KAP3.2和KAP6-1的转录水平；（2）IGF-Ⅰ在3 d内可降低拔毛皮肤中GHR的表达，6 d以上无明显影响；对剃毛皮肤中的GHR表达无显著影响。IGF-Ⅰ对拔毛皮肤中的IGF-Ⅰ和IGF-ⅠR的表达均无明显影响；对剃毛皮肤中IGF-Ⅰ的表达有明显的促进作用，但IGF-ⅠR的变化不明显。IGF-Ⅰ对拔毛皮肤和剃毛皮肤中的KAP3.2 和KAP6-1的表达都能显著提高，且表达模式也基本一致，KAP3.2的表达早于KAP6-1的表达。IGF-Ⅰ对绵羊皮肤中的GHR和IGF-ⅠR的表达均无显著影响，对KAP3.2和KAP6-1的表达能显著提高，但呈现出颠倒的特定时序性，这是否是外源性IGF-Ⅰ不能促进体内毛囊生长的原因所在，有待进一步研究。
The study investigated the effect of extrinsic IGF-Ⅰon modulation of sheepskin hair follicle growth. Thirty-six Xin jiang sheep were selected and divided into six groups at random. Both pro-scapulae sides of each animal were plucked and shaved respectively. The left cross sections of plucking, shaving and control were injected intradermally with 0.5 ml IGF-Ⅰ(10ngand#8226;ml-1). The various sheepskins were sampled respectively for 0,3 |
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The study investigated the effect of extrinsic IGF-Ⅰon modulation of sheepskin hair follicle growth. Thirty-six Xin jiang sheep were selected and divided into six groups at random. Both pro-scapulae sides of each animal were plucked and shaved respectively. The left cross sections of plucking, shaving and control were injected intradermally with 0.5 ml IGF-Ⅰ(10ngand#8226;ml-1). The various sheepskins were sampled respectively for 0,3</description><identifier>ISSN: 0578-1752</identifier><language>chi</language><subject>CUEROS Y PIELES ; CUIRS ET PEAUX ; EXPRESION GENICA ; EXPRESSION DES GENES ; FACTEUR DE CROISSANCE IGF ; FACTOR DE CRECIMIENTO IGF ; GENE EXPRESSION ; HAIR ; HIDES AND SKINS ; http://www.fao.org/aos/agrovoc#c_27527 ; http://www.fao.org/aos/agrovoc#c_34028 ; http://www.fao.org/aos/agrovoc#c_3471 ; http://www.fao.org/aos/agrovoc#c_3609 ; http://www.fao.org/aos/agrovoc#c_7030 ; INSULIN-LIKE GROWTH FACTOR ; OVIN ; OVINOS ; PELO ; POILS ; SHEEP</subject><ispartof>Chung-kuo nung yeh kʿo hsüeh, 2007-03, Vol.40 (3)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Li Yan</creatorcontrib><creatorcontrib>Liao Herong</creatorcontrib><creatorcontrib>Li Zhimian</creatorcontrib><title>Effect of IGF-Ⅰon expression of five related hair follicles in varied sheepskins</title><title>Chung-kuo nung yeh kʿo hsüeh</title><description>为探讨外源性IGF-Ⅰ对绵羊皮肤中毛囊生长调控的影响。选取36只新疆细毛羊，随机分成6组。在每只绵羊的左、右两侧肩胛前部分别进行拔毛、剃毛处理。同时在左侧肩胛前部的拔毛、剃毛和正常区的交叉处注射0.5ml IGF-Ⅰ（10ngand#8226;ml-1），然后在第0、3、6、9、12、50天采取皮样。用RT-PCR方法，测定各皮肤中GHR、IGF-Ⅰ、IGF-ⅠR、KAP3.2和KAP6-1的mRNA相对丰度。（1）IGF-Ⅰ可以下调正常皮肤中GHR基因的表达，对IGF-Ⅰ、IGF-ⅠR的表达没有显著的影响，能显著提高KAP3.2和KAP6-1的转录水平；（2）IGF-Ⅰ在3 d内可降低拔毛皮肤中GHR的表达，6 d以上无明显影响；对剃毛皮肤中的GHR表达无显著影响。IGF-Ⅰ对拔毛皮肤中的IGF-Ⅰ和IGF-ⅠR的表达均无明显影响；对剃毛皮肤中IGF-Ⅰ的表达有明显的促进作用，但IGF-ⅠR的变化不明显。IGF-Ⅰ对拔毛皮肤和剃毛皮肤中的KAP3.2 和KAP6-1的表达都能显著提高，且表达模式也基本一致，KAP3.2的表达早于KAP6-1的表达。IGF-Ⅰ对绵羊皮肤中的GHR和IGF-ⅠR的表达均无显著影响，对KAP3.2和KAP6-1的表达能显著提高，但呈现出颠倒的特定时序性，这是否是外源性IGF-Ⅰ不能促进体内毛囊生长的原因所在，有待进一步研究。
The study investigated the effect of extrinsic IGF-Ⅰon modulation of sheepskin hair follicle growth. Thirty-six Xin jiang sheep were selected and divided into six groups at random. Both pro-scapulae sides of each animal were plucked and shaved respectively. The left cross sections of plucking, shaving and control were injected intradermally with 0.5 ml IGF-Ⅰ(10ngand#8226;ml-1). The various sheepskins were sampled respectively for 0,3</description><subject>CUEROS Y PIELES</subject><subject>CUIRS ET PEAUX</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>FACTEUR DE CROISSANCE IGF</subject><subject>FACTOR DE CRECIMIENTO IGF</subject><subject>GENE EXPRESSION</subject><subject>HAIR</subject><subject>HIDES AND SKINS</subject><subject>http://www.fao.org/aos/agrovoc#c_27527</subject><subject>http://www.fao.org/aos/agrovoc#c_34028</subject><subject>http://www.fao.org/aos/agrovoc#c_3471</subject><subject>http://www.fao.org/aos/agrovoc#c_3609</subject><subject>http://www.fao.org/aos/agrovoc#c_7030</subject><subject>INSULIN-LIKE GROWTH FACTOR</subject><subject>OVIN</subject><subject>OVINOS</subject><subject>PELO</subject><subject>POILS</subject><subject>SHEEP</subject><issn>0578-1752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFikEOgjAQRbvQRKIcwaQXIBlqoLomoG5cGPek4lQmNpR0CPEC3sOzeRJZuHf1X977MxFBprdJqjO1EDEzXQGUytUuh0icS2uxGaS38rivks_r7TuJzz7gdJxw8pZGlAGdGfAmW0NBWu8cNQ5ZUidHE2gK3CL2_KCOV2JujWOMf7sU66q8FIfEGl-beyCui5MC0ACQ63Tzr38BCSo6FA</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Li Yan</creator><creator>Liao Herong</creator><creator>Li Zhimian</creator><scope>FBQ</scope></search><sort><creationdate>200703</creationdate><title>Effect of IGF-Ⅰon expression of five related hair follicles in varied sheepskins</title><author>Li Yan ; Liao Herong ; Li Zhimian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-fao_agris_CN20070006713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2007</creationdate><topic>CUEROS Y PIELES</topic><topic>CUIRS ET PEAUX</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>FACTEUR DE CROISSANCE IGF</topic><topic>FACTOR DE CRECIMIENTO IGF</topic><topic>GENE EXPRESSION</topic><topic>HAIR</topic><topic>HIDES AND SKINS</topic><topic>http://www.fao.org/aos/agrovoc#c_27527</topic><topic>http://www.fao.org/aos/agrovoc#c_34028</topic><topic>http://www.fao.org/aos/agrovoc#c_3471</topic><topic>http://www.fao.org/aos/agrovoc#c_3609</topic><topic>http://www.fao.org/aos/agrovoc#c_7030</topic><topic>INSULIN-LIKE GROWTH FACTOR</topic><topic>OVIN</topic><topic>OVINOS</topic><topic>PELO</topic><topic>POILS</topic><topic>SHEEP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li Yan</creatorcontrib><creatorcontrib>Liao Herong</creatorcontrib><creatorcontrib>Li Zhimian</creatorcontrib><collection>AGRIS</collection><jtitle>Chung-kuo nung yeh kʿo hsüeh</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li Yan</au><au>Liao Herong</au><au>Li Zhimian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of IGF-Ⅰon expression of five related hair follicles in varied sheepskins</atitle><jtitle>Chung-kuo nung yeh kʿo hsüeh</jtitle><date>2007-03</date><risdate>2007</risdate><volume>40</volume><issue>3</issue><issn>0578-1752</issn><abstract>为探讨外源性IGF-Ⅰ对绵羊皮肤中毛囊生长调控的影响。选取36只新疆细毛羊，随机分成6组。在每只绵羊的左、右两侧肩胛前部分别进行拔毛、剃毛处理。同时在左侧肩胛前部的拔毛、剃毛和正常区的交叉处注射0.5ml IGF-Ⅰ（10ngand#8226;ml-1），然后在第0、3、6、9、12、50天采取皮样。用RT-PCR方法，测定各皮肤中GHR、IGF-Ⅰ、IGF-ⅠR、KAP3.2和KAP6-1的mRNA相对丰度。（1）IGF-Ⅰ可以下调正常皮肤中GHR基因的表达，对IGF-Ⅰ、IGF-ⅠR的表达没有显著的影响，能显著提高KAP3.2和KAP6-1的转录水平；（2）IGF-Ⅰ在3 d内可降低拔毛皮肤中GHR的表达，6 d以上无明显影响；对剃毛皮肤中的GHR表达无显著影响。IGF-Ⅰ对拔毛皮肤中的IGF-Ⅰ和IGF-ⅠR的表达均无明显影响；对剃毛皮肤中IGF-Ⅰ的表达有明显的促进作用，但IGF-ⅠR的变化不明显。IGF-Ⅰ对拔毛皮肤和剃毛皮肤中的KAP3.2 和KAP6-1的表达都能显著提高，且表达模式也基本一致，KAP3.2的表达早于KAP6-1的表达。IGF-Ⅰ对绵羊皮肤中的GHR和IGF-ⅠR的表达均无显著影响，对KAP3.2和KAP6-1的表达能显著提高，但呈现出颠倒的特定时序性，这是否是外源性IGF-Ⅰ不能促进体内毛囊生长的原因所在，有待进一步研究。
The study investigated the effect of extrinsic IGF-Ⅰon modulation of sheepskin hair follicle growth. Thirty-six Xin jiang sheep were selected and divided into six groups at random. Both pro-scapulae sides of each animal were plucked and shaved respectively. The left cross sections of plucking, shaving and control were injected intradermally with 0.5 ml IGF-Ⅰ(10ngand#8226;ml-1). The various sheepskins were sampled respectively for 0,3</abstract></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | CUEROS Y PIELES CUIRS ET PEAUX EXPRESION GENICA EXPRESSION DES GENES FACTEUR DE CROISSANCE IGF FACTOR DE CRECIMIENTO IGF GENE EXPRESSION HAIR HIDES AND SKINS http://www.fao.org/aos/agrovoc#c_27527 http://www.fao.org/aos/agrovoc#c_34028 http://www.fao.org/aos/agrovoc#c_3471 http://www.fao.org/aos/agrovoc#c_3609 http://www.fao.org/aos/agrovoc#c_7030 INSULIN-LIKE GROWTH FACTOR OVIN OVINOS PELO POILS SHEEP |
| title | Effect of IGF-Ⅰon expression of five related hair follicles in varied sheepskins |
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