Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery
Introduction: Meningiomas represent about 15% of all intracranial neoplasms, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascul...
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| description | Introduction: Meningiomas represent about 15% of all intracranial neoplasms, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascular endothelial growth factor (VEGF) plays significant role in meningioma hypervascularity and PTE genesis that also influences the prognosis in surgically treated patients. Aim: The aim of our study was to investigate the influence of peritumoral edema and angiogenesis (VEGF expression), microvascular density, and proliferative cell potential on prognosis in aspect of morbidity and postoperative complications after intracranial meningioma surgery. Material and methods: The analysis of clinical, neuroradiological, and histological data, with follow-up period of at least one year, of 78 microsurgically treated patients with intracranial supratentorial meningioma was performed. Presence or absence of PTE was examined on preoperative CT scan or MRI, and width of PTE was measured in millimeters (in direction of maximal tumor diameter). Angiogenesis was evaluated by imunohistochemical analyses for detection of VEGF (level of imunoexpression), microvascular density (by marking blood vessels on CD34), and proliferative potential detection (with Ki-67 antigen in tumor tissue). Results: Severity of peritumoral edema (PTE) showed significant correlation with VEGF expression, and all patients with large PTE (> 40 mm) had high level of VEGF expression (> 50%). Treatment outcome was significantly better in patients with low VEGF expression (p |
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| fullrecord | <record><control><sourceid>europeana_1GC</sourceid><recordid>TN_cdi_europeana_collections_9200447_BibliographicResource_3000095543366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>9200447_BibliographicResource_3000095543366</sourcerecordid><originalsourceid>FETCH-europeana_collections_9200447_BibliographicResource_30000955433663</originalsourceid><addsrcrecordid>eNqtTUEKwjAQ7MWDqH_IB4Ri2kqvitKjiBdPZU23cSHNlk0i-Hsj-ASHGeYww8yyuF-ErecQyagXuISKRzWjUEwTCziFA06gwA9Zltiix0BBkc-MAkbAU65N6Omb525IYlHe62Ixggu4-fmq6M6n27HbYhKeETz0hp1DE4l96NtdWVbVvj_Qw-UbgflJ5oqBkxjsdZnR1nWlddPoP059AM8tV8M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>dissertation</recordtype></control><display><type>dissertation</type><title>Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery</title><source>Europeana Collections</source><creator>Marković Marko</creator><creatorcontrib>Marković Marko ; Antunović Vaso ; Nestorović Branislav ; Vuleković Petar ; Rakić Miodrag</creatorcontrib><description>Introduction: Meningiomas represent about 15% of all intracranial neoplasms, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascular endothelial growth factor (VEGF) plays significant role in meningioma hypervascularity and PTE genesis that also influences the prognosis in surgically treated patients. Aim: The aim of our study was to investigate the influence of peritumoral edema and angiogenesis (VEGF expression), microvascular density, and proliferative cell potential on prognosis in aspect of morbidity and postoperative complications after intracranial meningioma surgery. Material and methods: The analysis of clinical, neuroradiological, and histological data, with follow-up period of at least one year, of 78 microsurgically treated patients with intracranial supratentorial meningioma was performed. Presence or absence of PTE was examined on preoperative CT scan or MRI, and width of PTE was measured in millimeters (in direction of maximal tumor diameter). Angiogenesis was evaluated by imunohistochemical analyses for detection of VEGF (level of imunoexpression), microvascular density (by marking blood vessels on CD34), and proliferative potential detection (with Ki-67 antigen in tumor tissue). Results: Severity of peritumoral edema (PTE) showed significant correlation with VEGF expression, and all patients with large PTE (> 40 mm) had high level of VEGF expression (> 50%). Treatment outcome was significantly better in patients with low VEGF expression (p<0.05). All of the monitored postoperative complications were more frequent in the group with PTE. Duration of intensive care treatment in the group with PTE (mean: 6.85 days) was significantly longer than in the group without PTE (mean: 3.68 days; p=0.03). In the group without PTE, treatment outcome was significantly better than in patients with PTE (p<0.01). Conclusion: Peritumoral edema in intracranial meningiomas has significant influence on prognosis in surgically treated patients, in terms of increased risk of morbidity and postoperative complications. VEGF expression is strongly correlated with PTE formation, and also affects the outcome in the management of patients with intracranial meningioma.
Uvod: Meningiomi predstavljaju oko l5 % svih intrakranijalnih neoplazmi i po pravilu su benigni i ekstraaksijalni tumori, ali uprkos tome u preko 50% slučajeva praćeni su peritumorskim edemom što može uticati na težinu hirurške resekcije i prognozu lečenih pacijenata. Povećana ekspresija faktora angiogeneze, pre svega vaskularnog endotelijalnog faktora rasta (VEGF), značajno je povezana sa hipervaskularizacijom meningioma i peritumorskim edemom, što takođe može uticati na prognozu hirurški lečenih pacijenata. Cilj: Cilj naše prospektivne studije je bio da se ispita uticaj peritumorskog edema i angiogeneze (ekspresije VEGF), mikrovaskularne gustine, i proliferativnog ćelijskog potencijala na prognozu u smislu morbiditeta i postoperativnih komplikacija kod pacijenata operisanih od intrakranijalnih meningioma. Materijal i metode: Kod 78 pacijenata operisanih od intrakranijalnih meningioma supratentorijalne lokalizacije urađena je analiza kliničkih, neuroradioloških, i histopatoloških parametara sa periodom praćenja od najmanje godinu dana. Procena prisustva peritumorskog edema je izvršena na osnovu CT i/ili NMR pregleda i određena kvantitativno merenjem njegove širine izražene u milimetrima (u pravcu najšireg dijametra tumora). Angiogeneza je ispitivana imunohistohemijskom analizom VEGF (stepen imunoekspresije), mikrovaskularne gustine (markiranjem krvnih sudova na CD 34), i proliferativnog potencijala (sa Ki67 u tumorskom tkivu). Rezultati: Utvrđena je značajna korelacija veličine peritumorskog edema (PTE) sa ekspresijom VEGF, svi pacijenti sa velikim PTE (> 40 mm) imali su visok stepen ekspresije VEGF (> 50%). Ishod lečenja je bio značajno bolji kod pacijenata sa niskom ekspresijom VEGF (p<0.05). Sve zabeležene postoperativne komplikacije imale su veću učestalost u grupi sa PTE. Dužina lečenja u jedinici intenzivne nege u grupi sa PTE (prosečno: 6.85 dana) je bila značajno veća nego u grupi bez PTE (prosečno: 3.68 dana; p=0.03). U grupi pacijenata bez PTE ishod lečenja je bio značajno bolji nego kod pacijenata sa PTE (p<0.01). Zaključak: Peritumorski edem kod intrakranijalnih meningioma ima značajan uticaj na prognozu kod hirurški lečenih pacijenata u smislu povećanog rizika od morbiditeta i postoperativnih komplikacija. Ekspresija VEGF je značajno povezana sa stvaranjem PTE, i sa tim u vezi značajno utiče na ishod lečenja kod pacijenata sa intrakranijalnim meningiomima.</description><language>srp</language><publisher>University of Belgrade, Faculty of Medicine</publisher><subject>angiogenesis ; angiogeneza ; ekspresija VEGF ; Intracranial meningioma ; Intrakranijalni meningiomi ; ishod lečenja ; microvascular density ; mikrovaskularna gustina ; peritumoral edema ; peritumorski edem ; proliferative potential ; proliferativni potencijal ; treatment outcome ; VEGF expression</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://data.europeana.eu/item/9200447/BibliographicResource_3000095543366$$EHTML$$P50$$Geuropeana$$Hfree_for_read</linktohtml><link.rule.ids>311,780,38516,75947</link.rule.ids><linktorsrc>$$Uhttps://data.europeana.eu/item/9200447/BibliographicResource_3000095543366$$EView_record_in_Europeana$$FView_record_in_$$GEuropeana$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Marković Marko</creatorcontrib><title>Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery</title><description>Introduction: Meningiomas represent about 15% of all intracranial neoplasms, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascular endothelial growth factor (VEGF) plays significant role in meningioma hypervascularity and PTE genesis that also influences the prognosis in surgically treated patients. Aim: The aim of our study was to investigate the influence of peritumoral edema and angiogenesis (VEGF expression), microvascular density, and proliferative cell potential on prognosis in aspect of morbidity and postoperative complications after intracranial meningioma surgery. Material and methods: The analysis of clinical, neuroradiological, and histological data, with follow-up period of at least one year, of 78 microsurgically treated patients with intracranial supratentorial meningioma was performed. Presence or absence of PTE was examined on preoperative CT scan or MRI, and width of PTE was measured in millimeters (in direction of maximal tumor diameter). Angiogenesis was evaluated by imunohistochemical analyses for detection of VEGF (level of imunoexpression), microvascular density (by marking blood vessels on CD34), and proliferative potential detection (with Ki-67 antigen in tumor tissue). Results: Severity of peritumoral edema (PTE) showed significant correlation with VEGF expression, and all patients with large PTE (> 40 mm) had high level of VEGF expression (> 50%). Treatment outcome was significantly better in patients with low VEGF expression (p<0.05). All of the monitored postoperative complications were more frequent in the group with PTE. Duration of intensive care treatment in the group with PTE (mean: 6.85 days) was significantly longer than in the group without PTE (mean: 3.68 days; p=0.03). In the group without PTE, treatment outcome was significantly better than in patients with PTE (p<0.01). Conclusion: Peritumoral edema in intracranial meningiomas has significant influence on prognosis in surgically treated patients, in terms of increased risk of morbidity and postoperative complications. VEGF expression is strongly correlated with PTE formation, and also affects the outcome in the management of patients with intracranial meningioma.
Uvod: Meningiomi predstavljaju oko l5 % svih intrakranijalnih neoplazmi i po pravilu su benigni i ekstraaksijalni tumori, ali uprkos tome u preko 50% slučajeva praćeni su peritumorskim edemom što može uticati na težinu hirurške resekcije i prognozu lečenih pacijenata. Povećana ekspresija faktora angiogeneze, pre svega vaskularnog endotelijalnog faktora rasta (VEGF), značajno je povezana sa hipervaskularizacijom meningioma i peritumorskim edemom, što takođe može uticati na prognozu hirurški lečenih pacijenata. Cilj: Cilj naše prospektivne studije je bio da se ispita uticaj peritumorskog edema i angiogeneze (ekspresije VEGF), mikrovaskularne gustine, i proliferativnog ćelijskog potencijala na prognozu u smislu morbiditeta i postoperativnih komplikacija kod pacijenata operisanih od intrakranijalnih meningioma. Materijal i metode: Kod 78 pacijenata operisanih od intrakranijalnih meningioma supratentorijalne lokalizacije urađena je analiza kliničkih, neuroradioloških, i histopatoloških parametara sa periodom praćenja od najmanje godinu dana. Procena prisustva peritumorskog edema je izvršena na osnovu CT i/ili NMR pregleda i određena kvantitativno merenjem njegove širine izražene u milimetrima (u pravcu najšireg dijametra tumora). Angiogeneza je ispitivana imunohistohemijskom analizom VEGF (stepen imunoekspresije), mikrovaskularne gustine (markiranjem krvnih sudova na CD 34), i proliferativnog potencijala (sa Ki67 u tumorskom tkivu). Rezultati: Utvrđena je značajna korelacija veličine peritumorskog edema (PTE) sa ekspresijom VEGF, svi pacijenti sa velikim PTE (> 40 mm) imali su visok stepen ekspresije VEGF (> 50%). Ishod lečenja je bio značajno bolji kod pacijenata sa niskom ekspresijom VEGF (p<0.05). Sve zabeležene postoperativne komplikacije imale su veću učestalost u grupi sa PTE. Dužina lečenja u jedinici intenzivne nege u grupi sa PTE (prosečno: 6.85 dana) je bila značajno veća nego u grupi bez PTE (prosečno: 3.68 dana; p=0.03). U grupi pacijenata bez PTE ishod lečenja je bio značajno bolji nego kod pacijenata sa PTE (p<0.01). Zaključak: Peritumorski edem kod intrakranijalnih meningioma ima značajan uticaj na prognozu kod hirurški lečenih pacijenata u smislu povećanog rizika od morbiditeta i postoperativnih komplikacija. Ekspresija VEGF je značajno povezana sa stvaranjem PTE, i sa tim u vezi značajno utiče na ishod lečenja kod pacijenata sa intrakranijalnim meningiomima.</description><subject>angiogenesis</subject><subject>angiogeneza</subject><subject>ekspresija VEGF</subject><subject>Intracranial meningioma</subject><subject>Intrakranijalni meningiomi</subject><subject>ishod lečenja</subject><subject>microvascular density</subject><subject>mikrovaskularna gustina</subject><subject>peritumoral edema</subject><subject>peritumorski edem</subject><subject>proliferative potential</subject><subject>proliferativni potencijal</subject><subject>treatment outcome</subject><subject>VEGF expression</subject><fulltext>true</fulltext><rsrctype>dissertation</rsrctype><creationdate>2013</creationdate><recordtype>dissertation</recordtype><sourceid>1GC</sourceid><recordid>eNqtTUEKwjAQ7MWDqH_IB4Ri2kqvitKjiBdPZU23cSHNlk0i-Hsj-ASHGeYww8yyuF-ErecQyagXuISKRzWjUEwTCziFA06gwA9Zltiix0BBkc-MAkbAU65N6Omb525IYlHe62Ixggu4-fmq6M6n27HbYhKeETz0hp1DE4l96NtdWVbVvj_Qw-UbgflJ5oqBkxjsdZnR1nWlddPoP059AM8tV8M</recordid><startdate>20130423</startdate><enddate>20130423</enddate><creator>Marković Marko</creator><general>University of Belgrade, Faculty of Medicine</general><scope>1GC</scope></search><sort><creationdate>20130423</creationdate><title>Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery</title><author>Marković Marko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-europeana_collections_9200447_BibliographicResource_30000955433663</frbrgroupid><rsrctype>dissertations</rsrctype><prefilter>dissertations</prefilter><language>srp</language><creationdate>2013</creationdate><topic>angiogenesis</topic><topic>angiogeneza</topic><topic>ekspresija VEGF</topic><topic>Intracranial meningioma</topic><topic>Intrakranijalni meningiomi</topic><topic>ishod lečenja</topic><topic>microvascular density</topic><topic>mikrovaskularna gustina</topic><topic>peritumoral edema</topic><topic>peritumorski edem</topic><topic>proliferative potential</topic><topic>proliferativni potencijal</topic><topic>treatment outcome</topic><topic>VEGF expression</topic><toplevel>online_resources</toplevel><creatorcontrib>Marković Marko</creatorcontrib><collection>Europeana Collections</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Marković Marko</au><format>dissertation</format><genre>dissertation</genre><ristype>THES</ristype><Advisor>Antunović Vaso</Advisor><Advisor>Nestorović Branislav</Advisor><Advisor>Vuleković Petar</Advisor><Advisor>Rakić Miodrag</Advisor><btitle>Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery</btitle><date>2013-04-23</date><risdate>2013</risdate><abstract>Introduction: Meningiomas represent about 15% of all intracranial neoplasms, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascular endothelial growth factor (VEGF) plays significant role in meningioma hypervascularity and PTE genesis that also influences the prognosis in surgically treated patients. Aim: The aim of our study was to investigate the influence of peritumoral edema and angiogenesis (VEGF expression), microvascular density, and proliferative cell potential on prognosis in aspect of morbidity and postoperative complications after intracranial meningioma surgery. Material and methods: The analysis of clinical, neuroradiological, and histological data, with follow-up period of at least one year, of 78 microsurgically treated patients with intracranial supratentorial meningioma was performed. Presence or absence of PTE was examined on preoperative CT scan or MRI, and width of PTE was measured in millimeters (in direction of maximal tumor diameter). Angiogenesis was evaluated by imunohistochemical analyses for detection of VEGF (level of imunoexpression), microvascular density (by marking blood vessels on CD34), and proliferative potential detection (with Ki-67 antigen in tumor tissue). Results: Severity of peritumoral edema (PTE) showed significant correlation with VEGF expression, and all patients with large PTE (> 40 mm) had high level of VEGF expression (> 50%). Treatment outcome was significantly better in patients with low VEGF expression (p<0.05). All of the monitored postoperative complications were more frequent in the group with PTE. Duration of intensive care treatment in the group with PTE (mean: 6.85 days) was significantly longer than in the group without PTE (mean: 3.68 days; p=0.03). In the group without PTE, treatment outcome was significantly better than in patients with PTE (p<0.01). Conclusion: Peritumoral edema in intracranial meningiomas has significant influence on prognosis in surgically treated patients, in terms of increased risk of morbidity and postoperative complications. VEGF expression is strongly correlated with PTE formation, and also affects the outcome in the management of patients with intracranial meningioma.
Uvod: Meningiomi predstavljaju oko l5 % svih intrakranijalnih neoplazmi i po pravilu su benigni i ekstraaksijalni tumori, ali uprkos tome u preko 50% slučajeva praćeni su peritumorskim edemom što može uticati na težinu hirurške resekcije i prognozu lečenih pacijenata. Povećana ekspresija faktora angiogeneze, pre svega vaskularnog endotelijalnog faktora rasta (VEGF), značajno je povezana sa hipervaskularizacijom meningioma i peritumorskim edemom, što takođe može uticati na prognozu hirurški lečenih pacijenata. Cilj: Cilj naše prospektivne studije je bio da se ispita uticaj peritumorskog edema i angiogeneze (ekspresije VEGF), mikrovaskularne gustine, i proliferativnog ćelijskog potencijala na prognozu u smislu morbiditeta i postoperativnih komplikacija kod pacijenata operisanih od intrakranijalnih meningioma. Materijal i metode: Kod 78 pacijenata operisanih od intrakranijalnih meningioma supratentorijalne lokalizacije urađena je analiza kliničkih, neuroradioloških, i histopatoloških parametara sa periodom praćenja od najmanje godinu dana. Procena prisustva peritumorskog edema je izvršena na osnovu CT i/ili NMR pregleda i određena kvantitativno merenjem njegove širine izražene u milimetrima (u pravcu najšireg dijametra tumora). Angiogeneza je ispitivana imunohistohemijskom analizom VEGF (stepen imunoekspresije), mikrovaskularne gustine (markiranjem krvnih sudova na CD 34), i proliferativnog potencijala (sa Ki67 u tumorskom tkivu). Rezultati: Utvrđena je značajna korelacija veličine peritumorskog edema (PTE) sa ekspresijom VEGF, svi pacijenti sa velikim PTE (> 40 mm) imali su visok stepen ekspresije VEGF (> 50%). Ishod lečenja je bio značajno bolji kod pacijenata sa niskom ekspresijom VEGF (p<0.05). Sve zabeležene postoperativne komplikacije imale su veću učestalost u grupi sa PTE. Dužina lečenja u jedinici intenzivne nege u grupi sa PTE (prosečno: 6.85 dana) je bila značajno veća nego u grupi bez PTE (prosečno: 3.68 dana; p=0.03). U grupi pacijenata bez PTE ishod lečenja je bio značajno bolji nego kod pacijenata sa PTE (p<0.01). Zaključak: Peritumorski edem kod intrakranijalnih meningioma ima značajan uticaj na prognozu kod hirurški lečenih pacijenata u smislu povećanog rizika od morbiditeta i postoperativnih komplikacija. Ekspresija VEGF je značajno povezana sa stvaranjem PTE, i sa tim u vezi značajno utiče na ishod lečenja kod pacijenata sa intrakranijalnim meningiomima.</abstract><pub>University of Belgrade, Faculty of Medicine</pub><oa>free_for_read</oa></addata></record> |
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| subjects | angiogenesis angiogeneza ekspresija VEGF Intracranial meningioma Intrakranijalni meningiomi ishod lečenja microvascular density mikrovaskularna gustina peritumoral edema peritumorski edem proliferative potential proliferativni potencijal treatment outcome VEGF expression |
| title | Prognostic value of peritumoral edema and angiogenesis in intracranial meningioma surgery |
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