Labeled chemotactic peptides to image focal sites of infection or inflammation
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeuticall...
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| creator | DOUGLAS RIEXINGER CLAUDIA K DERIAN PEDRO E HERNANDEZ SCOTT K LARSEN H WILLIAM STRAUSS GARY J BRIDGER ROBERT H RUBIN ALAN J FISCHMAN HOWARD F SOLOMON ANTHONY J FUCCELLO JOHN D HIGGINS DANIEL J KROON |
| description | The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent. |
| format | Patent |
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CLAUDIA K DERIAN ; PEDRO E HERNANDEZ ; SCOTT K LARSEN ; H WILLIAM STRAUSS ; GARY J BRIDGER ; ROBERT H RUBIN ; ALAN J FISCHMAN ; HOWARD F SOLOMON ; ANTHONY J FUCCELLO ; JOHN D HIGGINS ; DANIEL J KROON</creatorcontrib><description>The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Labeled chemotactic peptides to image focal sites of infection or inflammation |
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