PROTEIN/POLYSACCHARIDE COMPLEXES

@ Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such as sutures, blood vessel grafts, and artificial organs. The biodegradable protein is preferably collag...

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Bibliographische Detailangaben
Hauptverfasser:	IAN ALEXANDER EASTON, STEPHEN DUDLEY GORHAM
Format:	Patent
Sprache:	eng
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES THEIR PREPARATION OR CHEMICAL WORKING-UP TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	@ Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such as sutures, blood vessel grafts, and artificial organs. The biodegradable protein is preferably collagen, and the polysaccharide is preferably sodium alginate. The complexes are preferably formed by combining the protein and the polysaccharide at a pH which is no higher than the isoelectric point of the protein. The complexes may be crosslinked, such as by dehydrothermal crosslinking or by the use of chemical crosslinking agents such as aldehydes or carbodiimides. Multivalent cations may also be incorporated in the complex in order to give added strength.