2,6-DIAMINONEBULARINES, THEIR PRODUCTION AND USE
NEW MATERIAL:The titled compound of formula I [R is 2-pyridyl or 3-pyridyl, both of which may be substituted] or its salt. EXAMPLE:N -(3-Pyridyl)-2,6-diaminonebularine. USE:Remedy for ischemic cardiopathies such as coronary insufficiency, stenocardia, or cardiac infarction: it show excellent action...
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| creator | SHUNSUKE SHIMA RYUJI MARUMOTO MASAO TANABE |
| description | NEW MATERIAL:The titled compound of formula I [R is 2-pyridyl or 3-pyridyl, both of which may be substituted] or its salt. EXAMPLE:N -(3-Pyridyl)-2,6-diaminonebularine. USE:Remedy for ischemic cardiopathies such as coronary insufficiency, stenocardia, or cardiac infarction: it show excellent action of coronary vasodilation with lessensed side effects such as hypotension and with low toxicity. PREPARATION:For example, ammonia is made to act on a compound of formula II (R -R are hydroxyl, which may be protected; A is active group capable of forming an amino group by reaction with ammonia), when necessary, protecting groups are removed to give the compound of formula I. The ammonia is preferably dissolved in a solvent such as methanol and used by 2-5 times the molor amount of the compound of formula II. |
| format | Patent |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | 2,6-DIAMINONEBULARINES, THEIR PRODUCTION AND USE |
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