NOVEL DERIVATIVES OF 2-HYDROXYMETHYL-1,3,4-OXADIAZOLE,THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION
Compounds of the formula WHEREIN R1 is hydrogen, aminocarbonyl or aminocarbonyl N-substituted by alkyl having up to 4 carbon atoms, R2 is halogen, alkoxy having up to 4 carbon atoms, alkyl having up to 4 carbon atoms, or trifluoromethyl N IS 0, 1, 2 OR 3 ARE PREPARED BY REACTING ETHYL HYDROXYACETIMI...
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| creator | THOMAS J HUGUET G RAYNAUD G FAURAN C DOUZON C |
| description | Compounds of the formula WHEREIN R1 is hydrogen, aminocarbonyl or aminocarbonyl N-substituted by alkyl having up to 4 carbon atoms, R2 is halogen, alkoxy having up to 4 carbon atoms, alkyl having up to 4 carbon atoms, or trifluoromethyl N IS 0, 1, 2 OR 3 ARE PREPARED BY REACTING ETHYL HYDROXYACETIMIDATE HYDROCHLORIDE WITH PHENYLHYDRAZIDE OR (R2)n-substituted phenylhydrazide. When R1 is other than hydrogen, that reaction product is reacting with an alkyl isocyanate, or reacted with phenylchloroformate followed by reaction with ammonia. The compounds possess analgesic, antiinflammatory, anticonvulsivant, tranquilizing, myorelaxant, antidepressive, vasodilatatory, diuretic, anti-ulcerous, antiarythmic, antiserotoninic, spasmolytic, hypotensive, antibronchocontrictive, anticholinergic and antiemetic properties. |
| format | Patent |
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When R1 is other than hydrogen, that reaction product is reacting with an alkyl isocyanate, or reacted with phenylchloroformate followed by reaction with ammonia. The compounds possess analgesic, antiinflammatory, anticonvulsivant, tranquilizing, myorelaxant, antidepressive, vasodilatatory, diuretic, anti-ulcerous, antiarythmic, antiserotoninic, spasmolytic, hypotensive, antibronchocontrictive, anticholinergic and antiemetic properties.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1974</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19741127&DB=EPODOC&CC=ZA&NR=74260B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19741127&DB=EPODOC&CC=ZA&NR=74260B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THOMAS J</creatorcontrib><creatorcontrib>HUGUET G</creatorcontrib><creatorcontrib>RAYNAUD G</creatorcontrib><creatorcontrib>FAURAN C</creatorcontrib><creatorcontrib>DOUZON C</creatorcontrib><title>NOVEL DERIVATIVES OF 2-HYDROXYMETHYL-1,3,4-OXADIAZOLE,THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION</title><description>Compounds of the formula WHEREIN R1 is hydrogen, aminocarbonyl or aminocarbonyl N-substituted by alkyl having up to 4 carbon atoms, R2 is halogen, alkoxy having up to 4 carbon atoms, alkyl having up to 4 carbon atoms, or trifluoromethyl N IS 0, 1, 2 OR 3 ARE PREPARED BY REACTING ETHYL HYDROXYACETIMIDATE HYDROCHLORIDE WITH PHENYLHYDRAZIDE OR (R2)n-substituted phenylhydrazide. When R1 is other than hydrogen, that reaction product is reacting with an alkyl isocyanate, or reacted with phenylchloroformate followed by reaction with ammonia. 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When R1 is other than hydrogen, that reaction product is reacting with an alkyl isocyanate, or reacted with phenylchloroformate followed by reaction with ammonia. The compounds possess analgesic, antiinflammatory, anticonvulsivant, tranquilizing, myorelaxant, antidepressive, vasodilatatory, diuretic, anti-ulcerous, antiarythmic, antiserotoninic, spasmolytic, hypotensive, antibronchocontrictive, anticholinergic and antiemetic properties.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | NOVEL DERIVATIVES OF 2-HYDROXYMETHYL-1,3,4-OXADIAZOLE,THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION |
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