MONOCLONAL ANTIBODIES THAT BIND SPECIFICALLY TO HUMAN TRBV9

MONOCLONAL ANTIBODIES THAT BIND SPECIFICALLY TO HUMAN TRBV9

The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a metho...

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Hauptverfasser: STAROVEROV, Dmitry Borisovich, IAKOVLEV, Pavel Andreevich, NEMANKIN, Timofey Aleksandrovich, MOROZOV, Dmitry Valentinovich, BRITANOVA, Olga Vladimirovna, MISORIN, Alexey Konstantinovich, VLADIMIROVA, Anna Konstantinovna, EVSTRATEVA, Anna Valentinovna, IVANOV, Roman Alekseevich, LUKYANOV, Sergey Anatolievich, SHELEVA, Mariia Aleksandrovna, ANIKINA, Arina Vitalevna
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.