LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS RELATED TO SAME

A device comprising a reaction structure and a device base. The reaction structure forms a plurality of reaction recesses for containing a reaction solution with a pH of less than or equal to about 5 or a pH greater than or equal to about 8 and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The device base is positioned beneath the reaction structure and comprises a plurality of light sensors, device circuitry, a plurality of light guides, a liner layer and a protection layer. The device circuitry electrically is coupled to the light sensors to transmit data signals based on photons detected by the light sensors, wherein the device circuitry is provided within dielectric material layers The light guides have input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess, the light guides extending into the device base from the input regions toward at least one corresponding light sensor and comprising at least one filter material that filters the excitation light and permits the light emissions to pass to the at least one corresponding light sensor. The liner layer extends about the side surfaces of each light guide and is positioned between each light guide and the device circuitry. The protection layer extends about each light guide and positioned between each light guide and the liner layer that prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry, wherein the protection layer is chemically inert with respect to the reaction solution.