PROCESS FOR PREPARING MODULATORS OF P300 AND/OR CBP

PROCESS FOR PREPARING MODULATORS OF P300 AND/OR CBP

A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defi...

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Bibliographische Detailangaben
Hauptverfasser: TADDEI, David Michel Adrien, MOREY, James Vaughan, HARBOTTLE, Gareth, MADELEY, John Paul, BAGULEY, Paul, LINDLEY, Colin, TREVORROW, Jonathan, WOOD, David, GILBERT, Donald Alan
Format: Patent
Sprache:eng
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Zusammenfassung:A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer.