PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN

A method for manipulating the fucosylated glycan content on a recombinant protein comprising inoculating a bioreactor with mammalian host cells expressing the recombinant protein, and culturing the mammalian host cells in a serum free, culture medium including from 10 to 100 ppb copper and from 50 t...

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Bibliographische Detailangaben
Hauptverfasser: TRENTALANGE, Michael T, LEISKE, Daniel R
Format: Patent
Sprache:eng
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