PHARMACEUTICAL COMPOSITION COMPRISING AN APL TYPE PEPTIDE

PHARMACEUTICAL COMPOSITION COMPRISING AN APL TYPE PEPTIDE

The invention is relate with a pharmaceutical composition comprising peptide type APL called identified as SEQ ID No. 1, sodium acetate buffer at pH 3.9 - 4.7; and at least one stabilizing sugar selected from sucrose or trehalose. This pharmaceutical composition is useful for manufacture of a medica...

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Hauptverfasser: BESADA PÉREZ, Vladimir Armando, GONZÁLEZ LÓPEZ, Luis Javier, DOMÍNGUEZ HORTA, María del Carmen, LOPEZ ABAD, Cruz Matilde
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creator BESADA PÉREZ, Vladimir Armando
GONZÁLEZ LÓPEZ, Luis Javier
DOMÍNGUEZ HORTA, María del Carmen
LOPEZ ABAD, Cruz Matilde
description The invention is relate with a pharmaceutical composition comprising peptide type APL called identified as SEQ ID No. 1, sodium acetate buffer at pH 3.9 - 4.7; and at least one stabilizing sugar selected from sucrose or trehalose. This pharmaceutical composition is useful for manufacture of a medicament for treating inflammatory diseases related to an increase of neutrophils or citrullination of proteins. These inflammatory diseases include rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), Alzheimer's disease, and hepatic and pulmonary fibrosis. The invention also discloses a method for the treatment of these diseases, through effective therapeutic administration of the pharmaceutical composition of APL-type peptide.
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