PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORƴ AND OTHER USES

PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORƴ AND OTHER USES

Disclosed herein are compounds of the formulas:as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-1...

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Hauptverfasser: BOLTON, Gary, BENDER, Christopher F, HOTEMA, Martha R, JIANG, Xin, SHELDON, Zachary S, KORNBERG, Brian, VISNICK, Melean, CAPRATHE, Bradley William, LEE, Chitase
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creator BOLTON, Gary
BENDER, Christopher F
HOTEMA, Martha R
JIANG, Xin
SHELDON, Zachary S
KORNBERG, Brian
VISNICK, Melean
CAPRATHE, Bradley William
LEE, Chitase
description Disclosed herein are compounds of the formulas:as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
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title PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORƴ AND OTHER USES
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