3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having...

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Hauptverfasser: SHAFER,CYNTHIA, PFISTER,KEITH,BRUCE SENDZIK,MARTIN, LEVELL,JULIAN,ROY, CHO,YOUNG,SHIN, CAFERRO,THOMAS, COSTALES,ABRAN,Q, LENOIR ,FRANCOIS LIU GANG, ZHAO,QIAN, TOURE,BAKARY-BARRY YANG,FAN, LEI,HAUANGSHU, SUTTON,JAMES, SHULTZ,MICHAEL,DAVID SMITH,TROY, PALERMO,MARK,G
Format: Patent
Sprache:eng
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Zusammenfassung:The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.