PREPARATION PROCESS OF THE SODIUM SALT OF ESOMEPRAZOLE

A preparation process of esomeprazole sodium substantially free of sulfone impurity including the steps of: a) combining either esomeprazole with a (C3-C8)-ketone or a mixture thereof, a sodium alkoxide, and a (C1-C5)-alcohol, or esomeprazole sodium with a (C3-C8)-ketone or a mixture thereof and a (...

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Hauptverfasser: BARTRA SANMARTI MARTI, SOLSONA ROCABERT JOAN GABRIEL, BERENGUER MAIMO RAMON
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creator BARTRA SANMARTI MARTI
SOLSONA ROCABERT JOAN GABRIEL
BERENGUER MAIMO RAMON
description A preparation process of esomeprazole sodium substantially free of sulfone impurity including the steps of: a) combining either esomeprazole with a (C3-C8)-ketone or a mixture thereof, a sodium alkoxide, and a (C1-C5)-alcohol, or esomeprazole sodium with a (C3-C8)-ketone or a mixture thereof and a (C1-C5)-alcohol; and b) recovering the esomeprazole sodium formed from the reaction media by filtration.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PREPARATION PROCESS OF THE SODIUM SALT OF ESOMEPRAZOLE
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