CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190
DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiy...
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| creator | GREEN CLIVE JOHANNESSON PETRA BIRCH ALAN MARTIN BARLIND JONAS GUNNAR BAUER UDO ANDREAS BUTLIN ROGER JOHN HOVLAND RAGNAR JOHANNSSON JAN MAGNUS PETERSSON ANNIKA ULRIKA LEACH ANDREW NOESKE ALEXANDER TOBIAS |
| description | DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof. |
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BAUER UDO ANDREAS ; BUTLIN ROGER JOHN ; HOVLAND RAGNAR ; JOHANNSSON JAN MAGNUS ; PETERSSON ANNIKA ULRIKA ; LEACH ANDREW ; NOESKE ALEXANDER TOBIAS</creatorcontrib><description>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111130&DB=EPODOC&CC=ZA&NR=201003979B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111130&DB=EPODOC&CC=ZA&NR=201003979B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GREEN CLIVE</creatorcontrib><creatorcontrib>JOHANNESSON PETRA</creatorcontrib><creatorcontrib>BIRCH ALAN MARTIN</creatorcontrib><creatorcontrib>BARLIND JONAS GUNNAR</creatorcontrib><creatorcontrib>BAUER UDO ANDREAS</creatorcontrib><creatorcontrib>BUTLIN ROGER JOHN</creatorcontrib><creatorcontrib>HOVLAND RAGNAR</creatorcontrib><creatorcontrib>JOHANNSSON JAN MAGNUS</creatorcontrib><creatorcontrib>PETERSSON ANNIKA ULRIKA</creatorcontrib><creatorcontrib>LEACH ANDREW</creatorcontrib><creatorcontrib>NOESKE ALEXANDER TOBIAS</creatorcontrib><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><description>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB2dgxycvT1j_RRcPb3DfAP9XMJVnAMVnBxdwwxVPD08_B08gzxDwpWMLQ04GFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8VGORgaGBgbGluaWTsbEqAEAT9kkkg</recordid><startdate>20111130</startdate><enddate>20111130</enddate><creator>GREEN CLIVE</creator><creator>JOHANNESSON PETRA</creator><creator>BIRCH ALAN MARTIN</creator><creator>BARLIND JONAS GUNNAR</creator><creator>BAUER UDO ANDREAS</creator><creator>BUTLIN ROGER JOHN</creator><creator>HOVLAND RAGNAR</creator><creator>JOHANNSSON JAN MAGNUS</creator><creator>PETERSSON ANNIKA ULRIKA</creator><creator>LEACH ANDREW</creator><creator>NOESKE ALEXANDER TOBIAS</creator><scope>EVB</scope></search><sort><creationdate>20111130</creationdate><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><author>GREEN CLIVE ; JOHANNESSON PETRA ; BIRCH ALAN MARTIN ; BARLIND JONAS GUNNAR ; BAUER UDO ANDREAS ; BUTLIN ROGER JOHN ; HOVLAND RAGNAR ; JOHANNSSON JAN MAGNUS ; PETERSSON ANNIKA ULRIKA ; LEACH ANDREW ; NOESKE ALEXANDER TOBIAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ZA201003979B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GREEN CLIVE</creatorcontrib><creatorcontrib>JOHANNESSON PETRA</creatorcontrib><creatorcontrib>BIRCH ALAN MARTIN</creatorcontrib><creatorcontrib>BARLIND JONAS GUNNAR</creatorcontrib><creatorcontrib>BAUER UDO ANDREAS</creatorcontrib><creatorcontrib>BUTLIN ROGER JOHN</creatorcontrib><creatorcontrib>HOVLAND RAGNAR</creatorcontrib><creatorcontrib>JOHANNSSON JAN MAGNUS</creatorcontrib><creatorcontrib>PETERSSON ANNIKA ULRIKA</creatorcontrib><creatorcontrib>LEACH ANDREW</creatorcontrib><creatorcontrib>NOESKE ALEXANDER TOBIAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GREEN CLIVE</au><au>JOHANNESSON PETRA</au><au>BIRCH ALAN MARTIN</au><au>BARLIND JONAS GUNNAR</au><au>BAUER UDO ANDREAS</au><au>BUTLIN ROGER JOHN</au><au>HOVLAND RAGNAR</au><au>JOHANNSSON JAN MAGNUS</au><au>PETERSSON ANNIKA ULRIKA</au><au>LEACH ANDREW</au><au>NOESKE ALEXANDER TOBIAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><date>2011-11-30</date><risdate>2011</risdate><abstract>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190 |
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