TRISUBSTITUTED 1,2,4-TRIAZOLES

The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to posit...

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Hauptverfasser: VAN ROOSBROECK YVES EMIEL MARIA, LESAGE ANNE SIMONE JOSEPHINE, VAN DEN KEYBUS FRANS ALFONS MARIA, DE BRUYN MARCEL FRANS LEOPOLD, DINKLO THEODORUS, ZHUANG WEI, MACDONALD GREGOR JAMES, THURING JOHANNES WILHELMUS JOHN F, DUFFY JAMES EDWARD STEWART
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creator VAN ROOSBROECK YVES EMIEL MARIA
LESAGE ANNE SIMONE JOSEPHINE
VAN DEN KEYBUS FRANS ALFONS MARIA
DE BRUYN MARCEL FRANS LEOPOLD
DINKLO THEODORUS
ZHUANG WEI
MACDONALD GREGOR JAMES
THURING JOHANNES WILHELMUS JOHN F
DUFFY JAMES EDWARD STEWART
description The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title TRISUBSTITUTED 1,2,4-TRIAZOLES
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