Four branched dendrimer-peg for conjugation to proteins and peptides

A polymeric dendrimer-like structure with four branches of monomethoxypolyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glyc...

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Hauptverfasser: RAMON HERNANDEZ, JOSE ANGEL, CASTRO ODIO, FIDEL RAUL, SAEZ MARTINEZ, VIVIAN MARIA, FERNANDEZ SANCHEZ, EDUARDO, PAEZ MEIRELES, ROLANDO
Format: Patent
Sprache:eng
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Zusammenfassung:A polymeric dendrimer-like structure with four branches of monomethoxypolyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.