Compounds with medicinal effects due to interaction with the glucocorticoid receptor
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently...
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| creator | GROVE, SIMON JAMES ANTHONY OHLMEYER, MICHAEL LITTLEWOOD, PETER THOMAS ALBERT SHERBORNE, BRAD KICZUN, MICHAEL JOHN KINGSBURY, CELIA HO, KOC-KAN KULTGEN, STEVEN G MORPHY, JOHN RICHARD HAMILTON, NIALL MORTON BROWN, ANGUS RICHARD |
| description | The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders. |
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OHLMEYER, MICHAEL ; LITTLEWOOD, PETER THOMAS ALBERT ; SHERBORNE, BRAD ; KICZUN, MICHAEL JOHN ; KINGSBURY, CELIA ; HO, KOC-KAN ; KULTGEN, STEVEN G ; MORPHY, JOHN RICHARD ; HAMILTON, NIALL MORTON ; BROWN, ANGUS RICHARD</creatorcontrib><description>The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090325&DB=EPODOC&CC=ZA&NR=200804643B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090325&DB=EPODOC&CC=ZA&NR=200804643B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GROVE, SIMON JAMES ANTHONY</creatorcontrib><creatorcontrib>OHLMEYER, MICHAEL</creatorcontrib><creatorcontrib>LITTLEWOOD, PETER THOMAS ALBERT</creatorcontrib><creatorcontrib>SHERBORNE, BRAD</creatorcontrib><creatorcontrib>KICZUN, MICHAEL JOHN</creatorcontrib><creatorcontrib>KINGSBURY, CELIA</creatorcontrib><creatorcontrib>HO, KOC-KAN</creatorcontrib><creatorcontrib>KULTGEN, STEVEN G</creatorcontrib><creatorcontrib>MORPHY, JOHN RICHARD</creatorcontrib><creatorcontrib>HAMILTON, NIALL MORTON</creatorcontrib><creatorcontrib>BROWN, ANGUS RICHARD</creatorcontrib><title>Compounds with medicinal effects due to interaction with the glucocorticoid receptor</title><description>The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwkAQBdA0FqLeYTyAEEwQWw2KB0hlE5bZHzOw2Vl2J3h9Cz2A1Wveuuo7nZMu0Rd6i000wwtLdIEwjmAr5BeQKUk0ZMcmGr_TJtArLKys2YRVPGUwkmneVqvRhYLdz021v9_67nFA0gElOUaEDc_Lsa7PdXtqm2vzz_kA5PA5fQ</recordid><startdate>20090325</startdate><enddate>20090325</enddate><creator>GROVE, SIMON JAMES ANTHONY</creator><creator>OHLMEYER, MICHAEL</creator><creator>LITTLEWOOD, PETER THOMAS ALBERT</creator><creator>SHERBORNE, BRAD</creator><creator>KICZUN, MICHAEL JOHN</creator><creator>KINGSBURY, CELIA</creator><creator>HO, KOC-KAN</creator><creator>KULTGEN, STEVEN G</creator><creator>MORPHY, JOHN RICHARD</creator><creator>HAMILTON, NIALL MORTON</creator><creator>BROWN, ANGUS RICHARD</creator><scope>EVB</scope></search><sort><creationdate>20090325</creationdate><title>Compounds with medicinal effects due to interaction with the glucocorticoid receptor</title><author>GROVE, SIMON JAMES ANTHONY ; 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Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Compounds with medicinal effects due to interaction with the glucocorticoid receptor |
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