SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions cont...

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Hauptverfasser:	Li XING, SHUANG LIU, Rajesh DEVRAJ, Terri L BOEHM, Huey SHIEH, Radhika M BLEVIS-BAL, Richard C DURLEY, Shaun R SELNESS, Kevin D JEROME, Jeff HITCHCOCK, Brian S HICKORY, Win NAING, Paul V RUCKER, Laura D MARRUFO, Aruna SAMBANDAM, Kevin F MCGEE, Edgardo ALVIRA, Balekudru DEVADAS, Heather M MADSEN, Michelle A PROMO, JOHN WALKER, Ian L SCOTT, Thomas OWEN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.